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COVID-19 for the Cardiologist: Basic Virology, Epidemiology, Cardiac Manifestations, and Potential Therapeutic Strategies

Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As it spreads across the world, it has overwhelmed health care systems, strangled the global economy, and led to a devastating loss of life....

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Autores principales: Atri, Deepak, Siddiqi, Hasan K., Lang, Joshua P., Nauffal, Victor, Morrow, David A., Bohula, Erin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151394/
https://www.ncbi.nlm.nih.gov/pubmed/32292848
http://dx.doi.org/10.1016/j.jacbts.2020.04.002
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author Atri, Deepak
Siddiqi, Hasan K.
Lang, Joshua P.
Nauffal, Victor
Morrow, David A.
Bohula, Erin A.
author_facet Atri, Deepak
Siddiqi, Hasan K.
Lang, Joshua P.
Nauffal, Victor
Morrow, David A.
Bohula, Erin A.
author_sort Atri, Deepak
collection PubMed
description Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As it spreads across the world, it has overwhelmed health care systems, strangled the global economy, and led to a devastating loss of life. Widespread efforts from regulators, clinicians, and scientists are driving a rapid expansion of knowledge of the SARS-CoV-2 virus and COVID-19. The authors review the most current data, with a focus on the basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. The authors discuss the basic virology, epidemiology, clinical manifestation, multiorgan consequences, and outcomes. With a focus on cardiovascular complications, they propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies.
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spelling pubmed-71513942020-05-29 COVID-19 for the Cardiologist: Basic Virology, Epidemiology, Cardiac Manifestations, and Potential Therapeutic Strategies Atri, Deepak Siddiqi, Hasan K. Lang, Joshua P. Nauffal, Victor Morrow, David A. Bohula, Erin A. JACC Basic Transl Sci STATE-OF-THE-ART REVIEW Coronavirus disease-2019 (COVID-19), a contagious disease caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has reached pandemic status. As it spreads across the world, it has overwhelmed health care systems, strangled the global economy, and led to a devastating loss of life. Widespread efforts from regulators, clinicians, and scientists are driving a rapid expansion of knowledge of the SARS-CoV-2 virus and COVID-19. The authors review the most current data, with a focus on the basic understanding of the mechanism(s) of disease and translation to the clinical syndrome and potential therapeutics. The authors discuss the basic virology, epidemiology, clinical manifestation, multiorgan consequences, and outcomes. With a focus on cardiovascular complications, they propose several mechanisms of injury. The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies. Elsevier 2020-04-10 /pmc/articles/PMC7151394/ /pubmed/32292848 http://dx.doi.org/10.1016/j.jacbts.2020.04.002 Text en © 2020 Published by Elsevier on behalf of the American College of Cardiology Foundation. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle STATE-OF-THE-ART REVIEW
Atri, Deepak
Siddiqi, Hasan K.
Lang, Joshua P.
Nauffal, Victor
Morrow, David A.
Bohula, Erin A.
COVID-19 for the Cardiologist: Basic Virology, Epidemiology, Cardiac Manifestations, and Potential Therapeutic Strategies
title COVID-19 for the Cardiologist: Basic Virology, Epidemiology, Cardiac Manifestations, and Potential Therapeutic Strategies
title_full COVID-19 for the Cardiologist: Basic Virology, Epidemiology, Cardiac Manifestations, and Potential Therapeutic Strategies
title_fullStr COVID-19 for the Cardiologist: Basic Virology, Epidemiology, Cardiac Manifestations, and Potential Therapeutic Strategies
title_full_unstemmed COVID-19 for the Cardiologist: Basic Virology, Epidemiology, Cardiac Manifestations, and Potential Therapeutic Strategies
title_short COVID-19 for the Cardiologist: Basic Virology, Epidemiology, Cardiac Manifestations, and Potential Therapeutic Strategies
title_sort covid-19 for the cardiologist: basic virology, epidemiology, cardiac manifestations, and potential therapeutic strategies
topic STATE-OF-THE-ART REVIEW
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151394/
https://www.ncbi.nlm.nih.gov/pubmed/32292848
http://dx.doi.org/10.1016/j.jacbts.2020.04.002
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