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The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study–6 Months Results

Background: The current treatment of Erectile Dysfunction (ED) is mainly based on the use of drugs that provide erections shortly after use but they do not really treat the problem. Stem cell therapy is a novel treatment with regenerative properties that can possibly treat erectile dysfunction. Meth...

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Autores principales: Protogerou, Vassilis, Beshari, Sara El, Michalopoulos, Efstathios, Mallis, Panagiotis, Chrysikos, Dimosthenis, Samolis, Alexandros A., Stavropoulos-Giokas, Catherine, Troupis, Theodoros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151592/
https://www.ncbi.nlm.nih.gov/pubmed/32197323
http://dx.doi.org/10.3390/medicines7030014
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author Protogerou, Vassilis
Beshari, Sara El
Michalopoulos, Efstathios
Mallis, Panagiotis
Chrysikos, Dimosthenis
Samolis, Alexandros A.
Stavropoulos-Giokas, Catherine
Troupis, Theodoros
author_facet Protogerou, Vassilis
Beshari, Sara El
Michalopoulos, Efstathios
Mallis, Panagiotis
Chrysikos, Dimosthenis
Samolis, Alexandros A.
Stavropoulos-Giokas, Catherine
Troupis, Theodoros
author_sort Protogerou, Vassilis
collection PubMed
description Background: The current treatment of Erectile Dysfunction (ED) is mainly based on the use of drugs that provide erections shortly after use but they do not really treat the problem. Stem cell therapy is a novel treatment with regenerative properties that can possibly treat erectile dysfunction. Methods: Five patients with erectile disease were treated with Adipose-Derived Stem Cells (ADSCs) and Platelet Lysate Plasma (PLP). ADSCs were obtained through abdominal liposuction and PLP was prepared after obtaining blood samples from peripheral veins. Erectile function was evaluated with the International Index of Erectile Function questionnaire (IIEF-5) questionnaire, penile triplex at the 1st, 3rd, 6th and 12th month post-treatment. A CT scan of the head, thorax and abdomen was done before treatment and at the 12th month. Results: IIEF-5 scores were improved in all patients at the 6th month although not in the same pattern in all patients. Peak Systolic Velocity (PSV) also improved at the 6th month in all patients but also with different patterns in each patient, while End Diastolic Velocity (EDV) was more variable. Two patients decreased the treatment they used in order to obtain erection (from Intracavernosal injections (ICI) they used PDE-5Is), two had unassisted erections and one had an initial improvement which decreased at the 6th month. There were no side effects noted. Conclusions: Stem cell therapy in combination with PLP appears to show some improvement in erectile function and has minimal side effects in the short term.
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spelling pubmed-71515922020-04-20 The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study–6 Months Results Protogerou, Vassilis Beshari, Sara El Michalopoulos, Efstathios Mallis, Panagiotis Chrysikos, Dimosthenis Samolis, Alexandros A. Stavropoulos-Giokas, Catherine Troupis, Theodoros Medicines (Basel) Article Background: The current treatment of Erectile Dysfunction (ED) is mainly based on the use of drugs that provide erections shortly after use but they do not really treat the problem. Stem cell therapy is a novel treatment with regenerative properties that can possibly treat erectile dysfunction. Methods: Five patients with erectile disease were treated with Adipose-Derived Stem Cells (ADSCs) and Platelet Lysate Plasma (PLP). ADSCs were obtained through abdominal liposuction and PLP was prepared after obtaining blood samples from peripheral veins. Erectile function was evaluated with the International Index of Erectile Function questionnaire (IIEF-5) questionnaire, penile triplex at the 1st, 3rd, 6th and 12th month post-treatment. A CT scan of the head, thorax and abdomen was done before treatment and at the 12th month. Results: IIEF-5 scores were improved in all patients at the 6th month although not in the same pattern in all patients. Peak Systolic Velocity (PSV) also improved at the 6th month in all patients but also with different patterns in each patient, while End Diastolic Velocity (EDV) was more variable. Two patients decreased the treatment they used in order to obtain erection (from Intracavernosal injections (ICI) they used PDE-5Is), two had unassisted erections and one had an initial improvement which decreased at the 6th month. There were no side effects noted. Conclusions: Stem cell therapy in combination with PLP appears to show some improvement in erectile function and has minimal side effects in the short term. MDPI 2020-03-18 /pmc/articles/PMC7151592/ /pubmed/32197323 http://dx.doi.org/10.3390/medicines7030014 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Protogerou, Vassilis
Beshari, Sara El
Michalopoulos, Efstathios
Mallis, Panagiotis
Chrysikos, Dimosthenis
Samolis, Alexandros A.
Stavropoulos-Giokas, Catherine
Troupis, Theodoros
The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study–6 Months Results
title The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study–6 Months Results
title_full The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study–6 Months Results
title_fullStr The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study–6 Months Results
title_full_unstemmed The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study–6 Months Results
title_short The Combined Use of Stem Cells and Platelet Lysate Plasma for the Treatment of Erectile Dysfunction: A Pilot Study–6 Months Results
title_sort combined use of stem cells and platelet lysate plasma for the treatment of erectile dysfunction: a pilot study–6 months results
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151592/
https://www.ncbi.nlm.nih.gov/pubmed/32197323
http://dx.doi.org/10.3390/medicines7030014
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