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“Balancing Expectations with Actual Realities”: Conversations with Clinicians and Scientists in the First Year of a High-Risk Childhood Cancer Precision Medicine Trial
Precision medicine is changing cancer care and placing new demands on oncology professionals. Precision medicine trials for high-risk childhood cancer exemplify these complexities. We assessed clinicians’ (n = 39) and scientists’ (n = 15) experiences in the first year of the PRecISion Medicine for C...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151613/ https://www.ncbi.nlm.nih.gov/pubmed/32075154 http://dx.doi.org/10.3390/jpm10010009 |
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author | McGill, Brittany C. Wakefield, Claire E. Hetherington, Kate Munro, Lachlan J. Warby, Meera Lau, Loretta Tyrrell, Vanessa Ziegler, David S. O’Brien, Tracey A. Marshall, Glenn M. Malkin, David Hansford, Jordan R. Tucker, Katherine M. Vetsch, Janine |
author_facet | McGill, Brittany C. Wakefield, Claire E. Hetherington, Kate Munro, Lachlan J. Warby, Meera Lau, Loretta Tyrrell, Vanessa Ziegler, David S. O’Brien, Tracey A. Marshall, Glenn M. Malkin, David Hansford, Jordan R. Tucker, Katherine M. Vetsch, Janine |
author_sort | McGill, Brittany C. |
collection | PubMed |
description | Precision medicine is changing cancer care and placing new demands on oncology professionals. Precision medicine trials for high-risk childhood cancer exemplify these complexities. We assessed clinicians’ (n = 39) and scientists’ (n = 15) experiences in the first year of the PRecISion Medicine for Children with Cancer (PRISM) trial for children and adolescents with high-risk cancers, through an in-depth semi-structured interview. We thematically analysed participants’ responses regarding their professional challenges, and measured oncologists’ knowledge of genetics and confidence with somatic and germline molecular test results. Both groups described positive early experiences with PRISM but were cognisant of managing parents’ expectations. Key challenges for clinicians included understanding and communicating genomic results, balancing biopsy risks, and drug access. Most oncologists rated ‘good’ knowledge of genetics, but a minority were ‘very confident’ in interpreting (25%), explaining (34.4%) and making treatment recommendations (18.8%) based on somatic genetic test results. Challenges for scientists included greater emotional impact of their work and balancing translational outputs with academic productivity. Continued tracking of these challenges across the course of the trial, while assessing the perspectives of a wider range of stakeholders, is critical to drive the ongoing development of a workforce equipped to manage the demands of paediatric precision medicine. |
format | Online Article Text |
id | pubmed-7151613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71516132020-04-20 “Balancing Expectations with Actual Realities”: Conversations with Clinicians and Scientists in the First Year of a High-Risk Childhood Cancer Precision Medicine Trial McGill, Brittany C. Wakefield, Claire E. Hetherington, Kate Munro, Lachlan J. Warby, Meera Lau, Loretta Tyrrell, Vanessa Ziegler, David S. O’Brien, Tracey A. Marshall, Glenn M. Malkin, David Hansford, Jordan R. Tucker, Katherine M. Vetsch, Janine J Pers Med Article Precision medicine is changing cancer care and placing new demands on oncology professionals. Precision medicine trials for high-risk childhood cancer exemplify these complexities. We assessed clinicians’ (n = 39) and scientists’ (n = 15) experiences in the first year of the PRecISion Medicine for Children with Cancer (PRISM) trial for children and adolescents with high-risk cancers, through an in-depth semi-structured interview. We thematically analysed participants’ responses regarding their professional challenges, and measured oncologists’ knowledge of genetics and confidence with somatic and germline molecular test results. Both groups described positive early experiences with PRISM but were cognisant of managing parents’ expectations. Key challenges for clinicians included understanding and communicating genomic results, balancing biopsy risks, and drug access. Most oncologists rated ‘good’ knowledge of genetics, but a minority were ‘very confident’ in interpreting (25%), explaining (34.4%) and making treatment recommendations (18.8%) based on somatic genetic test results. Challenges for scientists included greater emotional impact of their work and balancing translational outputs with academic productivity. Continued tracking of these challenges across the course of the trial, while assessing the perspectives of a wider range of stakeholders, is critical to drive the ongoing development of a workforce equipped to manage the demands of paediatric precision medicine. MDPI 2020-02-14 /pmc/articles/PMC7151613/ /pubmed/32075154 http://dx.doi.org/10.3390/jpm10010009 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article McGill, Brittany C. Wakefield, Claire E. Hetherington, Kate Munro, Lachlan J. Warby, Meera Lau, Loretta Tyrrell, Vanessa Ziegler, David S. O’Brien, Tracey A. Marshall, Glenn M. Malkin, David Hansford, Jordan R. Tucker, Katherine M. Vetsch, Janine “Balancing Expectations with Actual Realities”: Conversations with Clinicians and Scientists in the First Year of a High-Risk Childhood Cancer Precision Medicine Trial |
title | “Balancing Expectations with Actual Realities”: Conversations with Clinicians and Scientists in the First Year of a High-Risk Childhood Cancer Precision Medicine Trial |
title_full | “Balancing Expectations with Actual Realities”: Conversations with Clinicians and Scientists in the First Year of a High-Risk Childhood Cancer Precision Medicine Trial |
title_fullStr | “Balancing Expectations with Actual Realities”: Conversations with Clinicians and Scientists in the First Year of a High-Risk Childhood Cancer Precision Medicine Trial |
title_full_unstemmed | “Balancing Expectations with Actual Realities”: Conversations with Clinicians and Scientists in the First Year of a High-Risk Childhood Cancer Precision Medicine Trial |
title_short | “Balancing Expectations with Actual Realities”: Conversations with Clinicians and Scientists in the First Year of a High-Risk Childhood Cancer Precision Medicine Trial |
title_sort | “balancing expectations with actual realities”: conversations with clinicians and scientists in the first year of a high-risk childhood cancer precision medicine trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151613/ https://www.ncbi.nlm.nih.gov/pubmed/32075154 http://dx.doi.org/10.3390/jpm10010009 |
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