Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety

Targeted protein degradation using small chimeric molecules, such as proteolysis-targeting chimeras (PROTACs) and specific and nongenetic inhibitors of apoptosis protein [IAP]-dependent protein erasers (SNIPERs), is a promising technology in drug discovery. We recently developed a novel class of chi...

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Detalles Bibliográficos
Autores principales: Shoda, Takuji, Ohoka, Nobumichi, Tsuji, Genichiro, Fujisato, Takuma, Inoue, Hideshi, Demizu, Yosuke, Naito, Mikihiko, Kurihara, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151680/
https://www.ncbi.nlm.nih.gov/pubmed/32106507
http://dx.doi.org/10.3390/ph13030034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151680/
https://www.ncbi.nlm.nih.gov/pubmed/32106507
http://dx.doi.org/10.3390/ph13030034

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