Is There a Role for the Therapeutic Drug Monitoring of Colistin? An Overview

Colistin is used as a last-line antibiotic for the treatment of Gram-negative multiresistant bacteria. Due to its high nephrotoxicity, Therapeutic Drug Monitoring (TDM) is recommended for dose adjustment. We aimed to evaluate the available evidence of TDM in patients given colistin to treat Gram-neg...

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Autores principales: Avila, Maria-Paula, Pacheco, Tatiana, Arias, Sara, Bustos, Rosa-Helena, Garcia, Julio-Cesar, Jaimes, Diego
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151705/
https://www.ncbi.nlm.nih.gov/pubmed/32155714
http://dx.doi.org/10.3390/ph13030042
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author Avila, Maria-Paula
Pacheco, Tatiana
Arias, Sara
Bustos, Rosa-Helena
Garcia, Julio-Cesar
Jaimes, Diego
author_facet Avila, Maria-Paula
Pacheco, Tatiana
Arias, Sara
Bustos, Rosa-Helena
Garcia, Julio-Cesar
Jaimes, Diego
author_sort Avila, Maria-Paula
collection PubMed
description Colistin is used as a last-line antibiotic for the treatment of Gram-negative multiresistant bacteria. Due to its high nephrotoxicity, Therapeutic Drug Monitoring (TDM) is recommended for dose adjustment. We aimed to evaluate the available evidence of TDM in patients given colistin to treat Gram-negative infections. In this paper, we offer an overview, using an electronic search of the literature (published up to June 2019, without language restrictions) that compares the clinical outcomes and measurements of colistin TDM. Ultimately, the Therapeutic Drug Monitoring (TDM) of colistin in Plasma could prevent nephrotoxicity risk.
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spelling pubmed-71517052020-04-20 Is There a Role for the Therapeutic Drug Monitoring of Colistin? An Overview Avila, Maria-Paula Pacheco, Tatiana Arias, Sara Bustos, Rosa-Helena Garcia, Julio-Cesar Jaimes, Diego Pharmaceuticals (Basel) Brief Report Colistin is used as a last-line antibiotic for the treatment of Gram-negative multiresistant bacteria. Due to its high nephrotoxicity, Therapeutic Drug Monitoring (TDM) is recommended for dose adjustment. We aimed to evaluate the available evidence of TDM in patients given colistin to treat Gram-negative infections. In this paper, we offer an overview, using an electronic search of the literature (published up to June 2019, without language restrictions) that compares the clinical outcomes and measurements of colistin TDM. Ultimately, the Therapeutic Drug Monitoring (TDM) of colistin in Plasma could prevent nephrotoxicity risk. MDPI 2020-03-06 /pmc/articles/PMC7151705/ /pubmed/32155714 http://dx.doi.org/10.3390/ph13030042 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Avila, Maria-Paula
Pacheco, Tatiana
Arias, Sara
Bustos, Rosa-Helena
Garcia, Julio-Cesar
Jaimes, Diego
Is There a Role for the Therapeutic Drug Monitoring of Colistin? An Overview
title Is There a Role for the Therapeutic Drug Monitoring of Colistin? An Overview
title_full Is There a Role for the Therapeutic Drug Monitoring of Colistin? An Overview
title_fullStr Is There a Role for the Therapeutic Drug Monitoring of Colistin? An Overview
title_full_unstemmed Is There a Role for the Therapeutic Drug Monitoring of Colistin? An Overview
title_short Is There a Role for the Therapeutic Drug Monitoring of Colistin? An Overview
title_sort is there a role for the therapeutic drug monitoring of colistin? an overview
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151705/
https://www.ncbi.nlm.nih.gov/pubmed/32155714
http://dx.doi.org/10.3390/ph13030042
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