Comparative Modeling of Drug Target Proteins

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In this perspective, we begin by describing the comparative protein structure modeling technique and the accuracy of the corresponding models. We then discuss the significant role that comparative prediction plays in drug discovery. We focus on virtual ligand screening against comparative models and...

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Detalles Bibliográficos
Autores principales: Eswar, N., Sali, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151936/
http://dx.doi.org/10.1016/B0-08-045044-X/00251-0
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author Eswar, N.
Sali, A.
author_facet Eswar, N.
Sali, A.
author_sort Eswar, N.
collection PubMed
description In this perspective, we begin by describing the comparative protein structure modeling technique and the accuracy of the corresponding models. We then discuss the significant role that comparative prediction plays in drug discovery. We focus on virtual ligand screening against comparative models and illustrate the state of the art by a number of specific examples.
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spelling pubmed-71519362020-04-13 Comparative Modeling of Drug Target Proteins Eswar, N. Sali, A. Comprehensive Medicinal Chemistry II Article In this perspective, we begin by describing the comparative protein structure modeling technique and the accuracy of the corresponding models. We then discuss the significant role that comparative prediction plays in drug discovery. We focus on virtual ligand screening against comparative models and illustrate the state of the art by a number of specific examples. 2007 2007-04-11 /pmc/articles/PMC7151936/ http://dx.doi.org/10.1016/B0-08-045044-X/00251-0 Text en Copyright © 2007 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Eswar, N.
Sali, A.
Comparative Modeling of Drug Target Proteins
title Comparative Modeling of Drug Target Proteins
title_full Comparative Modeling of Drug Target Proteins
title_fullStr Comparative Modeling of Drug Target Proteins
title_full_unstemmed Comparative Modeling of Drug Target Proteins
title_short Comparative Modeling of Drug Target Proteins
title_sort comparative modeling of drug target proteins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151936/
http://dx.doi.org/10.1016/B0-08-045044-X/00251-0
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