5.14 The Biophysics of Membrane Fusion

A crucial interplay between protein conformations and lipid membrane energetics emerges as the guiding principle for the regulation and mechanism of membrane fusion in biological systems. As some of the basics of fusion become clear, a myriad of compelling questions come to the fore. Is the interior...

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Detalles Bibliográficos
Autores principales: Collins, R.N., Holz, R.W., Zimmerberg, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151979/
http://dx.doi.org/10.1016/B978-0-12-374920-8.00523-3
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author Collins, R.N.
Holz, R.W.
Zimmerberg, J.
author_facet Collins, R.N.
Holz, R.W.
Zimmerberg, J.
author_sort Collins, R.N.
collection PubMed
description A crucial interplay between protein conformations and lipid membrane energetics emerges as the guiding principle for the regulation and mechanism of membrane fusion in biological systems. As some of the basics of fusion become clear, a myriad of compelling questions come to the fore. Is the interior of the fusion pore protein or lipid? Why is synaptic release so fast? Why is PIP(2) needed for exocytosis? How does fusion peptide insertion lead to fusion of viruses to cell membranes? What role does the TMD play? How can studies on membrane fission contribute to our understanding of membrane fusion? What exactly are SNARE proteins doing?
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spelling pubmed-71519792020-04-13 5.14 The Biophysics of Membrane Fusion Collins, R.N. Holz, R.W. Zimmerberg, J. Comprehensive Biophysics Article A crucial interplay between protein conformations and lipid membrane energetics emerges as the guiding principle for the regulation and mechanism of membrane fusion in biological systems. As some of the basics of fusion become clear, a myriad of compelling questions come to the fore. Is the interior of the fusion pore protein or lipid? Why is synaptic release so fast? Why is PIP(2) needed for exocytosis? How does fusion peptide insertion lead to fusion of viruses to cell membranes? What role does the TMD play? How can studies on membrane fission contribute to our understanding of membrane fusion? What exactly are SNARE proteins doing? 2012 2012-05-03 /pmc/articles/PMC7151979/ http://dx.doi.org/10.1016/B978-0-12-374920-8.00523-3 Text en Copyright © 2012 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Collins, R.N.
Holz, R.W.
Zimmerberg, J.
5.14 The Biophysics of Membrane Fusion
title 5.14 The Biophysics of Membrane Fusion
title_full 5.14 The Biophysics of Membrane Fusion
title_fullStr 5.14 The Biophysics of Membrane Fusion
title_full_unstemmed 5.14 The Biophysics of Membrane Fusion
title_short 5.14 The Biophysics of Membrane Fusion
title_sort 5.14 the biophysics of membrane fusion
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151979/
http://dx.doi.org/10.1016/B978-0-12-374920-8.00523-3
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