Novel Evidence that Purinergic Signaling - Nlrp3 Inflammasome Axis Regulates Circadian Rhythm of Hematopoietic Stem/Progenitor Cells Circulation in Peripheral Blood

We found that circadian changes in ATP level in peripheral blood (PB) activate the Nlrp3 inflammasome, which triggers diurnal release of hematopoietic stem/progenitor cells (HSPCs) from murine bone marrow (BM) into PB. Consistent with this finding, we observed circadian changes in expression of mRNA...

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Detalles Bibliográficos
Autores principales: Adamiak, Mateusz, Ciechanowicz, Andrzej, Skoda, Marta, Cymer, Monika, Tracz, Michal, Xu, Bing, Ratajczak, Mariusz Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152586/
https://www.ncbi.nlm.nih.gov/pubmed/31939051
http://dx.doi.org/10.1007/s12015-020-09953-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152586/
https://www.ncbi.nlm.nih.gov/pubmed/31939051
http://dx.doi.org/10.1007/s12015-020-09953-0

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