Cargando…
Halting coronavirus polymerase
The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain termin...
| Autor principal: | |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152748/ https://www.ncbi.nlm.nih.gov/pubmed/32277065 http://dx.doi.org/10.1074/jbc.H120.013397 |
| _version_ | 1783521545260367872 |
|---|---|
| author | Kirchdoerfer, Robert N. |
| author_facet | Kirchdoerfer, Robert N. |
| author_sort | Kirchdoerfer, Robert N. |
| collection | PubMed |
| description | The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes. |
| format | Online Article Text |
| id | pubmed-7152748 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | American Society for Biochemistry and Molecular Biology |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71527482020-04-17 Halting coronavirus polymerase Kirchdoerfer, Robert N. J Biol Chem Editors' Picks Highlights The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes. American Society for Biochemistry and Molecular Biology 2020-04-10 /pmc/articles/PMC7152748/ /pubmed/32277065 http://dx.doi.org/10.1074/jbc.H120.013397 Text en © 2020 Kirchdoerfer. Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc. |
| spellingShingle | Editors' Picks Highlights Kirchdoerfer, Robert N. Halting coronavirus polymerase |
| title | Halting coronavirus polymerase |
| title_full | Halting coronavirus polymerase |
| title_fullStr | Halting coronavirus polymerase |
| title_full_unstemmed | Halting coronavirus polymerase |
| title_short | Halting coronavirus polymerase |
| title_sort | halting coronavirus polymerase |
| topic | Editors' Picks Highlights |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152748/ https://www.ncbi.nlm.nih.gov/pubmed/32277065 http://dx.doi.org/10.1074/jbc.H120.013397 |
| work_keys_str_mv | AT kirchdoerferrobertn haltingcoronaviruspolymerase |