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A Real-World Study of Prognosis of N0M0 Hepatocellular Carcinoma with Hepatic Resection Based on SEER Database

AIM: To develop and validate a simple-to-use nomogram for prediction of 3-/5-year survival in patients with N0M0 hepatocellular carcinoma after curative liver resection. Patients and Methods. Patients diagnosed HCC with hepatic resection in the Surveillance, Epidemiology, and End Results (SEER) data...

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Autores principales: Zhu, Guangxi, Wang, Wensheng, Liu, Qin, Chen, Dongfeng, Wen, Liangzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152960/
https://www.ncbi.nlm.nih.gov/pubmed/32328093
http://dx.doi.org/10.1155/2020/2357840
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author Zhu, Guangxi
Wang, Wensheng
Liu, Qin
Chen, Dongfeng
Wen, Liangzhi
author_facet Zhu, Guangxi
Wang, Wensheng
Liu, Qin
Chen, Dongfeng
Wen, Liangzhi
author_sort Zhu, Guangxi
collection PubMed
description AIM: To develop and validate a simple-to-use nomogram for prediction of 3-/5-year survival in patients with N0M0 hepatocellular carcinoma after curative liver resection. Patients and Methods. Patients diagnosed HCC with hepatic resection in the Surveillance, Epidemiology, and End Results (SEER) database were included to identify prognostic factors of overall survival. Multivariate Cox regression were used to create a nomogram. RESULTS: We identified 4856 HCC with hepatic resection from the SEER database. A nomogram to predict long-term survival with a C-index 0.667 (95% CI, 0.653 to 0.681) is more efficient than TNM staging with a lower C-index 0.613 (95% CI, 0.597 to 0.629). The C-index was confirmed to be 0.663 (95% CI, 0.640 to 0.686) through validation, suggesting a good discrimination and a good prediction capability. CONCLUSIONS: The nomogram is a simple and effective screening tool for assessing the prognosis of HCC with hepatic resection and assists with the planning of individual postoperative surveillance protocols.
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spelling pubmed-71529602020-04-23 A Real-World Study of Prognosis of N0M0 Hepatocellular Carcinoma with Hepatic Resection Based on SEER Database Zhu, Guangxi Wang, Wensheng Liu, Qin Chen, Dongfeng Wen, Liangzhi Gastroenterol Res Pract Research Article AIM: To develop and validate a simple-to-use nomogram for prediction of 3-/5-year survival in patients with N0M0 hepatocellular carcinoma after curative liver resection. Patients and Methods. Patients diagnosed HCC with hepatic resection in the Surveillance, Epidemiology, and End Results (SEER) database were included to identify prognostic factors of overall survival. Multivariate Cox regression were used to create a nomogram. RESULTS: We identified 4856 HCC with hepatic resection from the SEER database. A nomogram to predict long-term survival with a C-index 0.667 (95% CI, 0.653 to 0.681) is more efficient than TNM staging with a lower C-index 0.613 (95% CI, 0.597 to 0.629). The C-index was confirmed to be 0.663 (95% CI, 0.640 to 0.686) through validation, suggesting a good discrimination and a good prediction capability. CONCLUSIONS: The nomogram is a simple and effective screening tool for assessing the prognosis of HCC with hepatic resection and assists with the planning of individual postoperative surveillance protocols. Hindawi 2020-04-01 /pmc/articles/PMC7152960/ /pubmed/32328093 http://dx.doi.org/10.1155/2020/2357840 Text en Copyright © 2020 Guangxi Zhu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhu, Guangxi
Wang, Wensheng
Liu, Qin
Chen, Dongfeng
Wen, Liangzhi
A Real-World Study of Prognosis of N0M0 Hepatocellular Carcinoma with Hepatic Resection Based on SEER Database
title A Real-World Study of Prognosis of N0M0 Hepatocellular Carcinoma with Hepatic Resection Based on SEER Database
title_full A Real-World Study of Prognosis of N0M0 Hepatocellular Carcinoma with Hepatic Resection Based on SEER Database
title_fullStr A Real-World Study of Prognosis of N0M0 Hepatocellular Carcinoma with Hepatic Resection Based on SEER Database
title_full_unstemmed A Real-World Study of Prognosis of N0M0 Hepatocellular Carcinoma with Hepatic Resection Based on SEER Database
title_short A Real-World Study of Prognosis of N0M0 Hepatocellular Carcinoma with Hepatic Resection Based on SEER Database
title_sort real-world study of prognosis of n0m0 hepatocellular carcinoma with hepatic resection based on seer database
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152960/
https://www.ncbi.nlm.nih.gov/pubmed/32328093
http://dx.doi.org/10.1155/2020/2357840
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