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PD-L1 induction in tumor tissue after hypofractionated thoracic radiotherapy for non-small cell lung cancer

We report on a 67-year old male with advanced stage lung adenocarcinoma (initially PD-L1 negative, EGFR and ALK negative) diagnosed in 2014. The patient received 4 lines of palliative chemotherapy from 2014 to 2017, however the disease progressed. In 2015, he also received palliative hypofractionate...

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Detalles Bibliográficos
Autores principales: Narits, Jaanika, Tamm, Hannes, Jaal, Jana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153023/
https://www.ncbi.nlm.nih.gov/pubmed/32300664
http://dx.doi.org/10.1016/j.ctro.2020.04.003
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author Narits, Jaanika
Tamm, Hannes
Jaal, Jana
author_facet Narits, Jaanika
Tamm, Hannes
Jaal, Jana
author_sort Narits, Jaanika
collection PubMed
description We report on a 67-year old male with advanced stage lung adenocarcinoma (initially PD-L1 negative, EGFR and ALK negative) diagnosed in 2014. The patient received 4 lines of palliative chemotherapy from 2014 to 2017, however the disease progressed. In 2015, he also received palliative hypofractionated radiotherapy to a mediastinal mass, which was causing discomfort and pain. Since there was some data, that radiotherapy could induce PD-L1 expression, a new biopsy was taken in 2017 from the irradiated mediastinal mass. Subsequent pathologic report revealed that PD-L1 status was turned to be highly positive, with tumor proportion score of 100%. Similar high expression of PD-L1 was detected in a new metastasis in the duodenum, which was excised due to a duodenal perforation in 2017. From October 2017 to October 2019, the patient had 2-years of treatment (32 courses) with pembrolizumab and has had a positive effect (partial response) on all the lesions and following stabilization of the disease. Currently, this patient is under follow up and he is in a good condition without any complaints. Last CT-scan in March 2020 showed persisting partial response.
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spelling pubmed-71530232020-04-16 PD-L1 induction in tumor tissue after hypofractionated thoracic radiotherapy for non-small cell lung cancer Narits, Jaanika Tamm, Hannes Jaal, Jana Clin Transl Radiat Oncol Article We report on a 67-year old male with advanced stage lung adenocarcinoma (initially PD-L1 negative, EGFR and ALK negative) diagnosed in 2014. The patient received 4 lines of palliative chemotherapy from 2014 to 2017, however the disease progressed. In 2015, he also received palliative hypofractionated radiotherapy to a mediastinal mass, which was causing discomfort and pain. Since there was some data, that radiotherapy could induce PD-L1 expression, a new biopsy was taken in 2017 from the irradiated mediastinal mass. Subsequent pathologic report revealed that PD-L1 status was turned to be highly positive, with tumor proportion score of 100%. Similar high expression of PD-L1 was detected in a new metastasis in the duodenum, which was excised due to a duodenal perforation in 2017. From October 2017 to October 2019, the patient had 2-years of treatment (32 courses) with pembrolizumab and has had a positive effect (partial response) on all the lesions and following stabilization of the disease. Currently, this patient is under follow up and he is in a good condition without any complaints. Last CT-scan in March 2020 showed persisting partial response. Elsevier 2020-04-07 /pmc/articles/PMC7153023/ /pubmed/32300664 http://dx.doi.org/10.1016/j.ctro.2020.04.003 Text en © 2020 Published by Elsevier B.V. on behalf of European Society for Radiotherapy and Oncology. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Narits, Jaanika
Tamm, Hannes
Jaal, Jana
PD-L1 induction in tumor tissue after hypofractionated thoracic radiotherapy for non-small cell lung cancer
title PD-L1 induction in tumor tissue after hypofractionated thoracic radiotherapy for non-small cell lung cancer
title_full PD-L1 induction in tumor tissue after hypofractionated thoracic radiotherapy for non-small cell lung cancer
title_fullStr PD-L1 induction in tumor tissue after hypofractionated thoracic radiotherapy for non-small cell lung cancer
title_full_unstemmed PD-L1 induction in tumor tissue after hypofractionated thoracic radiotherapy for non-small cell lung cancer
title_short PD-L1 induction in tumor tissue after hypofractionated thoracic radiotherapy for non-small cell lung cancer
title_sort pd-l1 induction in tumor tissue after hypofractionated thoracic radiotherapy for non-small cell lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153023/
https://www.ncbi.nlm.nih.gov/pubmed/32300664
http://dx.doi.org/10.1016/j.ctro.2020.04.003
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