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New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi

[Image: see text] An antikinetoplastid pharmacomodulation study was conducted at position 6 of the 8-nitroquinolin-2(1H)-one pharmacophore. Fifteen new derivatives were synthesized and evaluated in vitro against L. infantum, T. brucei brucei, and T. cruzi, in parallel with a cytotoxicity assay on th...

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Detalles Bibliográficos
Autores principales:	Pedron, Julien, Boudot, Clotilde, Brossas, Jean-Yves, Pinault, Emilie, Bourgeade-Delmas, Sandra, Sournia-Saquet, Alix, Boutet-Robinet, Elisa, Destere, Alexandre, Tronnet, Antoine, Bergé, Justine, Bonduelle, Colin, Deraeve, Céline, Pratviel, Geneviève, Stigliani, Jean-Luc, Paris, Luc, Mazier, Dominique, Corvaisier, Sophie, Since, Marc, Malzert-Fréon, Aurélie, Wyllie, Susan, Milne, Rachel, Fairlamb, Alan H., Valentin, Alexis, Courtioux, Bertrand, Verhaeghe, Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153024/ https://www.ncbi.nlm.nih.gov/pubmed/32292551 http://dx.doi.org/10.1021/acsmedchemlett.9b00566

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