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Quasispecies dynamics in disease prevention and control
Medical interventions to prevent and treat viral disease constitute evolutionary forces that may modify the genetic composition of viral populations that replicate in an infected host and influence the genomic composition of those viruses that are transmitted and progress at the epidemiological leve...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153035/ http://dx.doi.org/10.1016/B978-0-12-816331-3.00008-8 |
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author | Domingo, Esteban |
author_facet | Domingo, Esteban |
author_sort | Domingo, Esteban |
collection | PubMed |
description | Medical interventions to prevent and treat viral disease constitute evolutionary forces that may modify the genetic composition of viral populations that replicate in an infected host and influence the genomic composition of those viruses that are transmitted and progress at the epidemiological level. Given the adaptive potential of viruses in general and the RNA viruses in particular, the selection of viral mutants that display some degree of resistance to inhibitors or vaccines is a tangible challenge. Mutant selection may jeopardize control of the viral disease. Strategies intended to minimize vaccination and treatment failures are proposed and justified based on fundamental features of viral dynamics explained in the preceding chapters. The recommended use of complex, multiepitopic vaccines, and combination therapies as early as possible after initiation of infection falls under the general concept that complexity cannot be combated with simplicity. It also follows that sociopolitical action to interrupt virus replication and spread as soon as possible is as important as scientifically sound treatment designs to control viral disease on a global scale. |
format | Online Article Text |
id | pubmed-7153035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
record_format | MEDLINE/PubMed |
spelling | pubmed-71530352020-04-13 Quasispecies dynamics in disease prevention and control Domingo, Esteban Virus as Populations Article Medical interventions to prevent and treat viral disease constitute evolutionary forces that may modify the genetic composition of viral populations that replicate in an infected host and influence the genomic composition of those viruses that are transmitted and progress at the epidemiological level. Given the adaptive potential of viruses in general and the RNA viruses in particular, the selection of viral mutants that display some degree of resistance to inhibitors or vaccines is a tangible challenge. Mutant selection may jeopardize control of the viral disease. Strategies intended to minimize vaccination and treatment failures are proposed and justified based on fundamental features of viral dynamics explained in the preceding chapters. The recommended use of complex, multiepitopic vaccines, and combination therapies as early as possible after initiation of infection falls under the general concept that complexity cannot be combated with simplicity. It also follows that sociopolitical action to interrupt virus replication and spread as soon as possible is as important as scientifically sound treatment designs to control viral disease on a global scale. 2020 2019-11-08 /pmc/articles/PMC7153035/ http://dx.doi.org/10.1016/B978-0-12-816331-3.00008-8 Text en Copyright © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Domingo, Esteban Quasispecies dynamics in disease prevention and control |
title | Quasispecies dynamics in disease prevention and control |
title_full | Quasispecies dynamics in disease prevention and control |
title_fullStr | Quasispecies dynamics in disease prevention and control |
title_full_unstemmed | Quasispecies dynamics in disease prevention and control |
title_short | Quasispecies dynamics in disease prevention and control |
title_sort | quasispecies dynamics in disease prevention and control |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153035/ http://dx.doi.org/10.1016/B978-0-12-816331-3.00008-8 |
work_keys_str_mv | AT domingoesteban quasispeciesdynamicsindiseasepreventionandcontrol |