Cargando…

Quasispecies dynamics in disease prevention and control

Medical interventions to prevent and treat viral disease constitute evolutionary forces that may modify the genetic composition of viral populations that replicate in an infected host and influence the genomic composition of those viruses that are transmitted and progress at the epidemiological leve...

Descripción completa

Detalles Bibliográficos
Autor principal: Domingo, Esteban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153035/
http://dx.doi.org/10.1016/B978-0-12-816331-3.00008-8
_version_ 1783521599100551168
author Domingo, Esteban
author_facet Domingo, Esteban
author_sort Domingo, Esteban
collection PubMed
description Medical interventions to prevent and treat viral disease constitute evolutionary forces that may modify the genetic composition of viral populations that replicate in an infected host and influence the genomic composition of those viruses that are transmitted and progress at the epidemiological level. Given the adaptive potential of viruses in general and the RNA viruses in particular, the selection of viral mutants that display some degree of resistance to inhibitors or vaccines is a tangible challenge. Mutant selection may jeopardize control of the viral disease. Strategies intended to minimize vaccination and treatment failures are proposed and justified based on fundamental features of viral dynamics explained in the preceding chapters. The recommended use of complex, multiepitopic vaccines, and combination therapies as early as possible after initiation of infection falls under the general concept that complexity cannot be combated with simplicity. It also follows that sociopolitical action to interrupt virus replication and spread as soon as possible is as important as scientifically sound treatment designs to control viral disease on a global scale.
format Online
Article
Text
id pubmed-7153035
institution National Center for Biotechnology Information
language English
publishDate 2020
record_format MEDLINE/PubMed
spelling pubmed-71530352020-04-13 Quasispecies dynamics in disease prevention and control Domingo, Esteban Virus as Populations Article Medical interventions to prevent and treat viral disease constitute evolutionary forces that may modify the genetic composition of viral populations that replicate in an infected host and influence the genomic composition of those viruses that are transmitted and progress at the epidemiological level. Given the adaptive potential of viruses in general and the RNA viruses in particular, the selection of viral mutants that display some degree of resistance to inhibitors or vaccines is a tangible challenge. Mutant selection may jeopardize control of the viral disease. Strategies intended to minimize vaccination and treatment failures are proposed and justified based on fundamental features of viral dynamics explained in the preceding chapters. The recommended use of complex, multiepitopic vaccines, and combination therapies as early as possible after initiation of infection falls under the general concept that complexity cannot be combated with simplicity. It also follows that sociopolitical action to interrupt virus replication and spread as soon as possible is as important as scientifically sound treatment designs to control viral disease on a global scale. 2020 2019-11-08 /pmc/articles/PMC7153035/ http://dx.doi.org/10.1016/B978-0-12-816331-3.00008-8 Text en Copyright © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Domingo, Esteban
Quasispecies dynamics in disease prevention and control
title Quasispecies dynamics in disease prevention and control
title_full Quasispecies dynamics in disease prevention and control
title_fullStr Quasispecies dynamics in disease prevention and control
title_full_unstemmed Quasispecies dynamics in disease prevention and control
title_short Quasispecies dynamics in disease prevention and control
title_sort quasispecies dynamics in disease prevention and control
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153035/
http://dx.doi.org/10.1016/B978-0-12-816331-3.00008-8
work_keys_str_mv AT domingoesteban quasispeciesdynamicsindiseasepreventionandcontrol