Epigenetic Significance of Chromatin Organization During Cellular Aging and Organismal Lifespan

Aging is a developmental process that occurs through epigenetic reprogramming that involves nine hallmark characteristics, most notably genomic instability. During physiological development, chromatin is modified, reorganized, and de-compacted in order for DNA to be transcribed, replicated, and repa...

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Autores principales: Georgieva, Milena, Staneva, Dessislava, Miloshev, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153164/
http://dx.doi.org/10.1007/978-3-319-25325-1_2
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author Georgieva, Milena
Staneva, Dessislava
Miloshev, George
author_facet Georgieva, Milena
Staneva, Dessislava
Miloshev, George
author_sort Georgieva, Milena
collection PubMed
description Aging is a developmental process that occurs through epigenetic reprogramming that involves nine hallmark characteristics, most notably genomic instability. During physiological development, chromatin is modified, reorganized, and de-compacted in order for DNA to be transcribed, replicated, and repaired. The most prominent histone modifications include acetylation, methylation, ubiquitylation, ADP-ribosylation, phosphorylation, and sumoylation. Younger cells/tissues are characterized by greater global methylation. Global DNA demethylation in aging occurs mainly at repetitive DNA elements and in genome regions with facultative heterochromatin, which leads to overall deheterochromatinization of the genome.
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spelling pubmed-71531642020-04-13 Epigenetic Significance of Chromatin Organization During Cellular Aging and Organismal Lifespan Georgieva, Milena Staneva, Dessislava Miloshev, George Epigenetics, the Environment, and Children’s Health Across Lifespans Article Aging is a developmental process that occurs through epigenetic reprogramming that involves nine hallmark characteristics, most notably genomic instability. During physiological development, chromatin is modified, reorganized, and de-compacted in order for DNA to be transcribed, replicated, and repaired. The most prominent histone modifications include acetylation, methylation, ubiquitylation, ADP-ribosylation, phosphorylation, and sumoylation. Younger cells/tissues are characterized by greater global methylation. Global DNA demethylation in aging occurs mainly at repetitive DNA elements and in genome regions with facultative heterochromatin, which leads to overall deheterochromatinization of the genome. 2016-02-09 /pmc/articles/PMC7153164/ http://dx.doi.org/10.1007/978-3-319-25325-1_2 Text en © Springer International Publishing Switzerland 2016 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Georgieva, Milena
Staneva, Dessislava
Miloshev, George
Epigenetic Significance of Chromatin Organization During Cellular Aging and Organismal Lifespan
title Epigenetic Significance of Chromatin Organization During Cellular Aging and Organismal Lifespan
title_full Epigenetic Significance of Chromatin Organization During Cellular Aging and Organismal Lifespan
title_fullStr Epigenetic Significance of Chromatin Organization During Cellular Aging and Organismal Lifespan
title_full_unstemmed Epigenetic Significance of Chromatin Organization During Cellular Aging and Organismal Lifespan
title_short Epigenetic Significance of Chromatin Organization During Cellular Aging and Organismal Lifespan
title_sort epigenetic significance of chromatin organization during cellular aging and organismal lifespan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153164/
http://dx.doi.org/10.1007/978-3-319-25325-1_2
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