Discovery of Membrane-Bound Pyrophosphatase Inhibitors Derived from an Isoxazole Fragment

[Image: see text] Membrane-bound pyrophosphatases (mPPases) regulate energy homeostasis in pathogenic protozoan parasites and lack human homologues, which makes them promising targets in e.g. malaria. Yet only few nonphosphorus inhibitors have been reported so far. Here, we explore an isoxazole frag...

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Detalles Bibliográficos
Autores principales: Johansson, Niklas G., Turku, Ainoleena, Vidilaseris, Keni, Dreano, Loïc, Khattab, Ayman, Ayuso Pérez, Daniel, Wilkinson, Aaron, Zhang, Yuezhou, Tamminen, Matti, Grazhdankin, Evgeni, Kiriazis, Alexandros, Fishwick, Colin W. G., Meri, Seppo, Yli-Kauhaluoma, Jari, Goldman, Adrian, Boije af Gennäs, Gustav, Xhaard, Henri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153278/
https://www.ncbi.nlm.nih.gov/pubmed/32292570
http://dx.doi.org/10.1021/acsmedchemlett.9b00537

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