Cargando…

Draft genome sequence data of Streptomyces sp. SS1-1, an endophytic strain showing cytotoxicity against the human lung cancer A549 cell line

We report in this article the cytotoxicity of Streptomyces sp. SS1-1 against the human lung cancer A549 cell line, its draft genome sequence and a total of 20 predicted secondary metabolite biosynthetic gene clusters. Streptomyces sp. SS1-1 was an endophytic bacterial strain isolated from the plant...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Quan Dang, Truong, Phung Minh, Vo, Thao Nguyen Thanh, Chu, Truc Dao Xuan, Nguyen, Chuong Hoang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153288/
https://www.ncbi.nlm.nih.gov/pubmed/32300629
http://dx.doi.org/10.1016/j.dib.2020.105497
_version_ 1783521621971042304
author Nguyen, Quan Dang
Truong, Phung Minh
Vo, Thao Nguyen Thanh
Chu, Truc Dao Xuan
Nguyen, Chuong Hoang
author_facet Nguyen, Quan Dang
Truong, Phung Minh
Vo, Thao Nguyen Thanh
Chu, Truc Dao Xuan
Nguyen, Chuong Hoang
author_sort Nguyen, Quan Dang
collection PubMed
description We report in this article the cytotoxicity of Streptomyces sp. SS1-1 against the human lung cancer A549 cell line, its draft genome sequence and a total of 20 predicted secondary metabolite biosynthetic gene clusters. Streptomyces sp. SS1-1 was an endophytic bacterial strain isolated from the plant Catharanthus roseus in Ho Chi Minh City, Vietnam. When cultured in the PY medium, this strain shows a cytotoxic effect on the A549 cell line. The draft genome of Streptomyces sp. SS1-1 has four contigs of total 7,815,656 bp and the GC content of this genome is 72.2%. AntiSMASH analysis reveals 20 putative biosynthetic gene clusters for the largest contig. The genome sequencing of Streptomyces sp. SS1-1 is essential for the molecular identification of gene cluster(s) responsible for secondary metabolite(s) with cytotoxic activity.
format Online
Article
Text
id pubmed-7153288
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-71532882020-04-16 Draft genome sequence data of Streptomyces sp. SS1-1, an endophytic strain showing cytotoxicity against the human lung cancer A549 cell line Nguyen, Quan Dang Truong, Phung Minh Vo, Thao Nguyen Thanh Chu, Truc Dao Xuan Nguyen, Chuong Hoang Data Brief Genetics, Genomics and Molecular Biology We report in this article the cytotoxicity of Streptomyces sp. SS1-1 against the human lung cancer A549 cell line, its draft genome sequence and a total of 20 predicted secondary metabolite biosynthetic gene clusters. Streptomyces sp. SS1-1 was an endophytic bacterial strain isolated from the plant Catharanthus roseus in Ho Chi Minh City, Vietnam. When cultured in the PY medium, this strain shows a cytotoxic effect on the A549 cell line. The draft genome of Streptomyces sp. SS1-1 has four contigs of total 7,815,656 bp and the GC content of this genome is 72.2%. AntiSMASH analysis reveals 20 putative biosynthetic gene clusters for the largest contig. The genome sequencing of Streptomyces sp. SS1-1 is essential for the molecular identification of gene cluster(s) responsible for secondary metabolite(s) with cytotoxic activity. Elsevier 2020-04-08 /pmc/articles/PMC7153288/ /pubmed/32300629 http://dx.doi.org/10.1016/j.dib.2020.105497 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Genetics, Genomics and Molecular Biology
Nguyen, Quan Dang
Truong, Phung Minh
Vo, Thao Nguyen Thanh
Chu, Truc Dao Xuan
Nguyen, Chuong Hoang
Draft genome sequence data of Streptomyces sp. SS1-1, an endophytic strain showing cytotoxicity against the human lung cancer A549 cell line
title Draft genome sequence data of Streptomyces sp. SS1-1, an endophytic strain showing cytotoxicity against the human lung cancer A549 cell line
title_full Draft genome sequence data of Streptomyces sp. SS1-1, an endophytic strain showing cytotoxicity against the human lung cancer A549 cell line
title_fullStr Draft genome sequence data of Streptomyces sp. SS1-1, an endophytic strain showing cytotoxicity against the human lung cancer A549 cell line
title_full_unstemmed Draft genome sequence data of Streptomyces sp. SS1-1, an endophytic strain showing cytotoxicity against the human lung cancer A549 cell line
title_short Draft genome sequence data of Streptomyces sp. SS1-1, an endophytic strain showing cytotoxicity against the human lung cancer A549 cell line
title_sort draft genome sequence data of streptomyces sp. ss1-1, an endophytic strain showing cytotoxicity against the human lung cancer a549 cell line
topic Genetics, Genomics and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153288/
https://www.ncbi.nlm.nih.gov/pubmed/32300629
http://dx.doi.org/10.1016/j.dib.2020.105497
work_keys_str_mv AT nguyenquandang draftgenomesequencedataofstreptomycesspss11anendophyticstrainshowingcytotoxicityagainstthehumanlungcancera549cellline
AT truongphungminh draftgenomesequencedataofstreptomycesspss11anendophyticstrainshowingcytotoxicityagainstthehumanlungcancera549cellline
AT vothaonguyenthanh draftgenomesequencedataofstreptomycesspss11anendophyticstrainshowingcytotoxicityagainstthehumanlungcancera549cellline
AT chutrucdaoxuan draftgenomesequencedataofstreptomycesspss11anendophyticstrainshowingcytotoxicityagainstthehumanlungcancera549cellline
AT nguyenchuonghoang draftgenomesequencedataofstreptomycesspss11anendophyticstrainshowingcytotoxicityagainstthehumanlungcancera549cellline