Neurotropic Coronavirus Infections

Neurotropic strains of the mouse hepatitis virus (MHV) cause a range of diseases in infected mice ranging from mild encephalitis with clearance of the virus followed by demyelination to rapidly fatal encephalitis. This chapter discusses the structure, life cycle, transmission, and pathology of neuro...

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Detalles Bibliográficos
Autores principales: Perlman, Stanley, Wheeler, D. Lori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153443/
http://dx.doi.org/10.1007/978-3-319-33133-1_5
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author Perlman, Stanley
Wheeler, D. Lori
author_facet Perlman, Stanley
Wheeler, D. Lori
author_sort Perlman, Stanley
collection PubMed
description Neurotropic strains of the mouse hepatitis virus (MHV) cause a range of diseases in infected mice ranging from mild encephalitis with clearance of the virus followed by demyelination to rapidly fatal encephalitis. This chapter discusses the structure, life cycle, transmission, and pathology of neurotropic coronaviruses, as well as the immune response to coronavirus infection. Mice infected with neurotropic strains of MHV have provided useful systems in which to study processes of virus- and immune-mediated demyelination and virus clearance and/or persistence in the CNS, and the mechanisms of virus evasion of the immune system.
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spelling pubmed-71534432020-04-13 Neurotropic Coronavirus Infections Perlman, Stanley Wheeler, D. Lori Neurotropic Viral Infections Article Neurotropic strains of the mouse hepatitis virus (MHV) cause a range of diseases in infected mice ranging from mild encephalitis with clearance of the virus followed by demyelination to rapidly fatal encephalitis. This chapter discusses the structure, life cycle, transmission, and pathology of neurotropic coronaviruses, as well as the immune response to coronavirus infection. Mice infected with neurotropic strains of MHV have provided useful systems in which to study processes of virus- and immune-mediated demyelination and virus clearance and/or persistence in the CNS, and the mechanisms of virus evasion of the immune system. 2016-09-09 /pmc/articles/PMC7153443/ http://dx.doi.org/10.1007/978-3-319-33133-1_5 Text en © Springer International Publishing Switzerland 2016 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Perlman, Stanley
Wheeler, D. Lori
Neurotropic Coronavirus Infections
title Neurotropic Coronavirus Infections
title_full Neurotropic Coronavirus Infections
title_fullStr Neurotropic Coronavirus Infections
title_full_unstemmed Neurotropic Coronavirus Infections
title_short Neurotropic Coronavirus Infections
title_sort neurotropic coronavirus infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153443/
http://dx.doi.org/10.1007/978-3-319-33133-1_5
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