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Distinct Origins of Restricted Progenitors in Postnatal Mouse Blood
BACKGROUND: Most researchers have accepted that unipotent progenitors are the predominant components in bone marrow for tissue regeneration. However, the unipotent progenitors for blood components are still unclear. We previously found that erythrocytes are derived from a distinct unipotent progenit...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elmer Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153665/ https://www.ncbi.nlm.nih.gov/pubmed/32300453 http://dx.doi.org/10.14740/jh540 |
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author | Kong, Wuyi Han, Xiujuan Wang, Hong Zhu, Xiaoping |
author_facet | Kong, Wuyi Han, Xiujuan Wang, Hong Zhu, Xiaoping |
author_sort | Kong, Wuyi |
collection | PubMed |
description | BACKGROUND: Most researchers have accepted that unipotent progenitors are the predominant components in bone marrow for tissue regeneration. However, the unipotent progenitors for blood components are still unclear. We previously found that erythrocytes are derived from a distinct unipotent progenitors, or erythrocyte sacs. METHODS: In the current study, we investigated if the other types of unipotent blood cell progenitors existed, what was their original morphologies, and the mechanism of their generation in mouse blood. RESULTS: We found two morphologically distinct structures that released spore-like small progenitors in mouse blood. One structure was filamentary-like, contained inclusions, widened due to differentiation of the inclusions, and eventually, released spore-like DNA+ and cluster of differentiation 34 (CD34)(+) spore-like small progenitors. Another structure was bud-like, contained inclusion, enlarged from less than 10 µm to more than 30 µm, and also released many spore-like small progenitors. Each type of these spore-like progenitors was approximately 1 µm in diameter and could continue to transdifferentiate in circulation. CONCLUSIONS: Our data provide evidence that two types of blood cell restricted progenitors are produced from either filamentary structures or bud-like structures. Both filamentary and bud-like structures were originally released from morphologically distinct, or lineage predetermined tube-shaped structures, or specific niches. Thus, distinct lineages of blood unipotent progenitors are newly produced. |
format | Online Article Text |
id | pubmed-7153665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elmer Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-71536652020-04-16 Distinct Origins of Restricted Progenitors in Postnatal Mouse Blood Kong, Wuyi Han, Xiujuan Wang, Hong Zhu, Xiaoping J Hematol Original Article BACKGROUND: Most researchers have accepted that unipotent progenitors are the predominant components in bone marrow for tissue regeneration. However, the unipotent progenitors for blood components are still unclear. We previously found that erythrocytes are derived from a distinct unipotent progenitors, or erythrocyte sacs. METHODS: In the current study, we investigated if the other types of unipotent blood cell progenitors existed, what was their original morphologies, and the mechanism of their generation in mouse blood. RESULTS: We found two morphologically distinct structures that released spore-like small progenitors in mouse blood. One structure was filamentary-like, contained inclusions, widened due to differentiation of the inclusions, and eventually, released spore-like DNA+ and cluster of differentiation 34 (CD34)(+) spore-like small progenitors. Another structure was bud-like, contained inclusion, enlarged from less than 10 µm to more than 30 µm, and also released many spore-like small progenitors. Each type of these spore-like progenitors was approximately 1 µm in diameter and could continue to transdifferentiate in circulation. CONCLUSIONS: Our data provide evidence that two types of blood cell restricted progenitors are produced from either filamentary structures or bud-like structures. Both filamentary and bud-like structures were originally released from morphologically distinct, or lineage predetermined tube-shaped structures, or specific niches. Thus, distinct lineages of blood unipotent progenitors are newly produced. Elmer Press 2019-09 2019-09-30 /pmc/articles/PMC7153665/ /pubmed/32300453 http://dx.doi.org/10.14740/jh540 Text en Copyright 2019, Kong et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kong, Wuyi Han, Xiujuan Wang, Hong Zhu, Xiaoping Distinct Origins of Restricted Progenitors in Postnatal Mouse Blood |
title | Distinct Origins of Restricted Progenitors in Postnatal Mouse Blood |
title_full | Distinct Origins of Restricted Progenitors in Postnatal Mouse Blood |
title_fullStr | Distinct Origins of Restricted Progenitors in Postnatal Mouse Blood |
title_full_unstemmed | Distinct Origins of Restricted Progenitors in Postnatal Mouse Blood |
title_short | Distinct Origins of Restricted Progenitors in Postnatal Mouse Blood |
title_sort | distinct origins of restricted progenitors in postnatal mouse blood |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153665/ https://www.ncbi.nlm.nih.gov/pubmed/32300453 http://dx.doi.org/10.14740/jh540 |
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