ALS IMPLICATED PROTEIN TDP-43 SUSTAINS LEVELS OF STMN2 A MEDIATOR OF MOTOR NEURON GROWTH AND REPAIR

The findings that ALS patients almost universally display pathological mislocalization of the RNA-binding protein TDP-43 and that mutations in its gene cause familial ALS have nominated altered RNA metabolism as a disease mechanism. However, the RNAs regulated by TDP-43 in motor neurons and their co...

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Detalles Bibliográficos
Autores principales: Klim, Joseph R., Williams, Luis A., Limone, Francesco, Juan, Irune Guerra San, Davis-Dusenbery, Brandi N., Mordes, Daniel A., Burberry, Aaron, Steinbaugh, Michael J., Gamage, Kanchana K., Kirchner, Rory, Moccia, Rob, Cassel, Seth H., Chen, Kuchuan, Wainger, Brian J., Woolf, Clifford J., Eggan, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153761/
https://www.ncbi.nlm.nih.gov/pubmed/30643292
http://dx.doi.org/10.1038/s41593-018-0300-4

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