Wheldone: Characterization of a Unique Scaffold from the Coculture of Aspergillus fischeri and Xylaria flabelliformis

[Image: see text] Wheldone (1) was isolated and elucidated from a coculture of Aspergillus fischeri (NRRL 181) and Xylaria flabelliformis (G536), where secondary metabolite biosynthesis was stimulated by antagonism between these fungi. First observed via in situ analysis between these competing fung...

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Autores principales: Knowles, Sonja L., Raja, Huzefa A., Isawi, Israa H., Flores-Bocanegra, Laura, Reggio, Patricia H., Pearce, Cedric J., Burdette, Joanna E., Rokas, Antonis, Oberlies, Nicholas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153779/
https://www.ncbi.nlm.nih.gov/pubmed/32096649
http://dx.doi.org/10.1021/acs.orglett.0c00219
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author Knowles, Sonja L.
Raja, Huzefa A.
Isawi, Israa H.
Flores-Bocanegra, Laura
Reggio, Patricia H.
Pearce, Cedric J.
Burdette, Joanna E.
Rokas, Antonis
Oberlies, Nicholas H.
author_facet Knowles, Sonja L.
Raja, Huzefa A.
Isawi, Israa H.
Flores-Bocanegra, Laura
Reggio, Patricia H.
Pearce, Cedric J.
Burdette, Joanna E.
Rokas, Antonis
Oberlies, Nicholas H.
author_sort Knowles, Sonja L.
collection PubMed
description [Image: see text] Wheldone (1) was isolated and elucidated from a coculture of Aspergillus fischeri (NRRL 181) and Xylaria flabelliformis (G536), where secondary metabolite biosynthesis was stimulated by antagonism between these fungi. First observed via in situ analysis between these competing fungal cultures, the conditions were scaled to reproducibly generate 1, whose novel structure was elucidated by one- and two-dimensional NMR and mass spectrometry. Compound 1 displayed cytotoxic activity against breast, ovarian, and melanoma cancer cell lines.
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spelling pubmed-71537792020-04-14 Wheldone: Characterization of a Unique Scaffold from the Coculture of Aspergillus fischeri and Xylaria flabelliformis Knowles, Sonja L. Raja, Huzefa A. Isawi, Israa H. Flores-Bocanegra, Laura Reggio, Patricia H. Pearce, Cedric J. Burdette, Joanna E. Rokas, Antonis Oberlies, Nicholas H. Org Lett [Image: see text] Wheldone (1) was isolated and elucidated from a coculture of Aspergillus fischeri (NRRL 181) and Xylaria flabelliformis (G536), where secondary metabolite biosynthesis was stimulated by antagonism between these fungi. First observed via in situ analysis between these competing fungal cultures, the conditions were scaled to reproducibly generate 1, whose novel structure was elucidated by one- and two-dimensional NMR and mass spectrometry. Compound 1 displayed cytotoxic activity against breast, ovarian, and melanoma cancer cell lines. American Chemical Society 2020-02-25 2020-03-06 /pmc/articles/PMC7153779/ /pubmed/32096649 http://dx.doi.org/10.1021/acs.orglett.0c00219 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Knowles, Sonja L.
Raja, Huzefa A.
Isawi, Israa H.
Flores-Bocanegra, Laura
Reggio, Patricia H.
Pearce, Cedric J.
Burdette, Joanna E.
Rokas, Antonis
Oberlies, Nicholas H.
Wheldone: Characterization of a Unique Scaffold from the Coculture of Aspergillus fischeri and Xylaria flabelliformis
title Wheldone: Characterization of a Unique Scaffold from the Coculture of Aspergillus fischeri and Xylaria flabelliformis
title_full Wheldone: Characterization of a Unique Scaffold from the Coculture of Aspergillus fischeri and Xylaria flabelliformis
title_fullStr Wheldone: Characterization of a Unique Scaffold from the Coculture of Aspergillus fischeri and Xylaria flabelliformis
title_full_unstemmed Wheldone: Characterization of a Unique Scaffold from the Coculture of Aspergillus fischeri and Xylaria flabelliformis
title_short Wheldone: Characterization of a Unique Scaffold from the Coculture of Aspergillus fischeri and Xylaria flabelliformis
title_sort wheldone: characterization of a unique scaffold from the coculture of aspergillus fischeri and xylaria flabelliformis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153779/
https://www.ncbi.nlm.nih.gov/pubmed/32096649
http://dx.doi.org/10.1021/acs.orglett.0c00219
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