The role of TRPV1 channels in atherosclerosis

Transient receptor potential vanilloid subfamily member 1 (TRPV1) is a nonselective cation channel, that is mainly distributed in sensory nerve endings and can release a variety of neurotransmitters after activation. Early studies showed that it mainly conducts pain sensation, but research has demon...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Chenyang, Ye, Lifang, Zhang, Qinggang, Wu, Fei, Wang, Lihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153790/
https://www.ncbi.nlm.nih.gov/pubmed/32274960
http://dx.doi.org/10.1080/19336950.2020.1747803
_version_ 1783521709489389568
author Zhang, Chenyang
Ye, Lifang
Zhang, Qinggang
Wu, Fei
Wang, Lihong
author_facet Zhang, Chenyang
Ye, Lifang
Zhang, Qinggang
Wu, Fei
Wang, Lihong
author_sort Zhang, Chenyang
collection PubMed
description Transient receptor potential vanilloid subfamily member 1 (TRPV1) is a nonselective cation channel, that is mainly distributed in sensory nerve endings and can release a variety of neurotransmitters after activation. Early studies showed that it mainly conducts pain sensation, but research has demonstrated that it also plays an important role in cardiovascular diseases. Notably, in atherosclerosis, the activation of TRPV1 can regulate lipid metabolism, reduce foam cell formation, protect endothelial cells, inhibit smooth muscle cell proliferation and inhibit inflammation and oxidation. In this review, the role of the TRPV1 channel in atherosclerosis was discussed to provide new ideas for the prevention and treatment of atherosclerotic diseases.
format Online
Article
Text
id pubmed-7153790
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-71537902020-04-20 The role of TRPV1 channels in atherosclerosis Zhang, Chenyang Ye, Lifang Zhang, Qinggang Wu, Fei Wang, Lihong Channels (Austin) Review Transient receptor potential vanilloid subfamily member 1 (TRPV1) is a nonselective cation channel, that is mainly distributed in sensory nerve endings and can release a variety of neurotransmitters after activation. Early studies showed that it mainly conducts pain sensation, but research has demonstrated that it also plays an important role in cardiovascular diseases. Notably, in atherosclerosis, the activation of TRPV1 can regulate lipid metabolism, reduce foam cell formation, protect endothelial cells, inhibit smooth muscle cell proliferation and inhibit inflammation and oxidation. In this review, the role of the TRPV1 channel in atherosclerosis was discussed to provide new ideas for the prevention and treatment of atherosclerotic diseases. Taylor & Francis 2020-04-10 /pmc/articles/PMC7153790/ /pubmed/32274960 http://dx.doi.org/10.1080/19336950.2020.1747803 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Zhang, Chenyang
Ye, Lifang
Zhang, Qinggang
Wu, Fei
Wang, Lihong
The role of TRPV1 channels in atherosclerosis
title The role of TRPV1 channels in atherosclerosis
title_full The role of TRPV1 channels in atherosclerosis
title_fullStr The role of TRPV1 channels in atherosclerosis
title_full_unstemmed The role of TRPV1 channels in atherosclerosis
title_short The role of TRPV1 channels in atherosclerosis
title_sort role of trpv1 channels in atherosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153790/
https://www.ncbi.nlm.nih.gov/pubmed/32274960
http://dx.doi.org/10.1080/19336950.2020.1747803
work_keys_str_mv AT zhangchenyang theroleoftrpv1channelsinatherosclerosis
AT yelifang theroleoftrpv1channelsinatherosclerosis
AT zhangqinggang theroleoftrpv1channelsinatherosclerosis
AT wufei theroleoftrpv1channelsinatherosclerosis
AT wanglihong theroleoftrpv1channelsinatherosclerosis
AT zhangchenyang roleoftrpv1channelsinatherosclerosis
AT yelifang roleoftrpv1channelsinatherosclerosis
AT zhangqinggang roleoftrpv1channelsinatherosclerosis
AT wufei roleoftrpv1channelsinatherosclerosis
AT wanglihong roleoftrpv1channelsinatherosclerosis

Ejemplares similares