Regulation of the cold-sensing TRPM8 channels by phosphoinositides and G(q)-coupled receptors

The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)]. This review discus...

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Detalles Bibliográficos
Autores principales: Liu, Luyu, Rohacs, Tibor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153793/
https://www.ncbi.nlm.nih.gov/pubmed/32101066
http://dx.doi.org/10.1080/19336950.2020.1734266
Descripción
Sumario:The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)]. This review discusses recent findings on the role of PI(4,5)P(2) and G-proteins in the modulation of TRPM8 upon receptor activation. We will also summarize knowledge on the role of PI(4,5)P(2) in Ca(2+) dependent desensitization/adaptation of TRPM8 activity, and recent advances in the structural basis of how this lipid binds to TRPM8.

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