Regulation of the cold-sensing TRPM8 channels by phosphoinositides and G(q)-coupled receptors

The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)]. This review discus...

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Autores principales: Liu, Luyu, Rohacs, Tibor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153793/
https://www.ncbi.nlm.nih.gov/pubmed/32101066
http://dx.doi.org/10.1080/19336950.2020.1734266
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author Liu, Luyu
Rohacs, Tibor
author_facet Liu, Luyu
Rohacs, Tibor
author_sort Liu, Luyu
collection PubMed
description The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)]. This review discusses recent findings on the role of PI(4,5)P(2) and G-proteins in the modulation of TRPM8 upon receptor activation. We will also summarize knowledge on the role of PI(4,5)P(2) in Ca(2+) dependent desensitization/adaptation of TRPM8 activity, and recent advances in the structural basis of how this lipid binds to TRPM8.
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spelling pubmed-71537932020-04-20 Regulation of the cold-sensing TRPM8 channels by phosphoinositides and G(q)-coupled receptors Liu, Luyu Rohacs, Tibor Channels (Austin) Review The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)]. This review discusses recent findings on the role of PI(4,5)P(2) and G-proteins in the modulation of TRPM8 upon receptor activation. We will also summarize knowledge on the role of PI(4,5)P(2) in Ca(2+) dependent desensitization/adaptation of TRPM8 activity, and recent advances in the structural basis of how this lipid binds to TRPM8. Taylor & Francis 2020-02-26 /pmc/articles/PMC7153793/ /pubmed/32101066 http://dx.doi.org/10.1080/19336950.2020.1734266 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Liu, Luyu
Rohacs, Tibor
Regulation of the cold-sensing TRPM8 channels by phosphoinositides and G(q)-coupled receptors
title Regulation of the cold-sensing TRPM8 channels by phosphoinositides and G(q)-coupled receptors
title_full Regulation of the cold-sensing TRPM8 channels by phosphoinositides and G(q)-coupled receptors
title_fullStr Regulation of the cold-sensing TRPM8 channels by phosphoinositides and G(q)-coupled receptors
title_full_unstemmed Regulation of the cold-sensing TRPM8 channels by phosphoinositides and G(q)-coupled receptors
title_short Regulation of the cold-sensing TRPM8 channels by phosphoinositides and G(q)-coupled receptors
title_sort regulation of the cold-sensing trpm8 channels by phosphoinositides and g(q)-coupled receptors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153793/
https://www.ncbi.nlm.nih.gov/pubmed/32101066
http://dx.doi.org/10.1080/19336950.2020.1734266
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