Identification and characterization of M6903, an antagonistic anti–TIM-3 monoclonal antibody

T cell immunoglobulin and mucin domain-3 (TIM-3) is an immune checkpoint that regulates normal immune responses but can be exploited by tumor cells to evade immune surveillance. TIM-3 is primarily expressed on immune cells, particularly on dysfunctional and exhausted T cells, and engagement of TIM-3...

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Detalles Bibliográficos
Autores principales: Zhang, Dong, Jiang, Feng, Zaynagetdinov, Rinat, Huang, Hui, Sood, Vanita D., Wang, Hong, Zhao, Xinyan, Jenkins, Molly H., Ji, Qingyong, Wang, Youbin, Nannemann, David P., Musil, Djordje, Wesolowski, John, Paoletti, Andrea, Bartholomew, Tin, Derner, Melissa G., An, Qi, Iffland, Christel, Halle, Joern-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153820/
https://www.ncbi.nlm.nih.gov/pubmed/32313722
http://dx.doi.org/10.1080/2162402X.2020.1744921

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