Antibody CDR loops as ensembles in solution vs. canonical clusters from X-ray structures

In the past decade, the relevance of antibodies as therapeutics has increased substantially. Therefore, structural and functional characterization, in particular of the complementarity-determining regions (CDRs), is crucial to the design and engineering of antibodies with unique binding properties....

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Detalles Bibliográficos
Autores principales: Fernández-Quintero, Monica L., Heiss, Martin C., Pomarici, Nancy D., Math, Barbara A., Liedl, Klaus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153821/
https://www.ncbi.nlm.nih.gov/pubmed/32264741
http://dx.doi.org/10.1080/19420862.2020.1744328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153821/
https://www.ncbi.nlm.nih.gov/pubmed/32264741
http://dx.doi.org/10.1080/19420862.2020.1744328

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