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Antibody CDR loops as ensembles in solution vs. canonical clusters from X-ray structures
In the past decade, the relevance of antibodies as therapeutics has increased substantially. Therefore, structural and functional characterization, in particular of the complementarity-determining regions (CDRs), is crucial to the design and engineering of antibodies with unique binding properties....
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153821/ https://www.ncbi.nlm.nih.gov/pubmed/32264741 http://dx.doi.org/10.1080/19420862.2020.1744328 |