Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumors

Mesothelin (MSLN) is a cell surface glycoprotein overexpressed in several solid malignancies, including gastric, lung, mesothelioma, pancreatic and ovarian cancers. While several MSLN-targeting therapeutic approaches are in development, only limited efficacy has been achieved in patients. A potentia...

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Detalles Bibliográficos
Autores principales: Hatterer, Eric, Chauchet, Xavier, Richard, Françoise, Barba, Leticia, Moine, Valéry, Chatel, Laurence, Broyer, Lucile, Pontini, Guillemette, Bautzova, Tereza, Juan, Flora, Calloud, Sebastien, Bosson, Nicolas, Charreton, Maud, Masternak, Krzysztof, Buatois, Vanessa, Shang, Limin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153835/
https://www.ncbi.nlm.nih.gov/pubmed/32191151
http://dx.doi.org/10.1080/19420862.2020.1739408

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