Dose escalation PET imaging for safety and effective therapy dose optimization of a bispecific antibody

Selecting the dose for efficacy and first-in-human studies of bispecific antibodies (BsAbs) is a challenging process. Herein, positron emission tomography (PET) imaging with (89)Zr-labeled IBI322, an anti-CD47/PD-L1 BsAb, was used to optimize the safety and effective therapy dose. By labeling with (...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Pan, Donghui, Huang, Chenrong, Chen, Bingliang, Li, Mingzhu, Zhou, Shuaixiang, Wang, Lizhen, Wu, Min, Wang, Xinyu, Bian, Yicong, Yan, Junjie, Liu, Junjian, Yang, Min, Miao, Liyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153848/
https://www.ncbi.nlm.nih.gov/pubmed/32275842
http://dx.doi.org/10.1080/19420862.2020.1748322

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