Contribution of Rare Variants of the SLC22A12 Gene to the Missing Heritability of Serum Urate Levels

Gout is a common arthritis caused by monosodium urate crystals. The heritability of serum urate levels is estimated to be 30–70%; however, common genetic variants account for only 7.9% of the variance in serum urate levels. This discrepancy is an example of “missing heritability.” The “missing herit...

Descripción completa

Detalles Bibliográficos
Autores principales: Misawa, Kazuharu, Hasegawa, Takanori, Mishima, Eikan, Jutabha, Promsuk, Ouchi, Motoshi, Kojima, Kaname, Kawai, Yosuke, Matsuo, Masafumi, Anzai, Naohiko, Nagasaki, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2020
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153932/
https://www.ncbi.nlm.nih.gov/pubmed/32005656
http://dx.doi.org/10.1534/genetics.119.303006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153932/
https://www.ncbi.nlm.nih.gov/pubmed/32005656
http://dx.doi.org/10.1534/genetics.119.303006

Ejemplares similares