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Contribution of Rare Variants of the SLC22A12 Gene to the Missing Heritability of Serum Urate Levels

Gout is a common arthritis caused by monosodium urate crystals. The heritability of serum urate levels is estimated to be 30–70%; however, common genetic variants account for only 7.9% of the variance in serum urate levels. This discrepancy is an example of “missing heritability.” The “missing herit...

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Detalles Bibliográficos
Autores principales:	Misawa, Kazuharu, Hasegawa, Takanori, Mishima, Eikan, Jutabha, Promsuk, Ouchi, Motoshi, Kojima, Kaname, Kawai, Yosuke, Matsuo, Masafumi, Anzai, Naohiko, Nagasaki, Masao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2020
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153932/ https://www.ncbi.nlm.nih.gov/pubmed/32005656 http://dx.doi.org/10.1534/genetics.119.303006

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