The Role of Exosomal microRNA in Cancer Drug Resistance

Exosomes affect the initiation and progression of cancers. In the tumor microenvironment, not only cancer cells, but also fibroblasts and immunocytes secrete exosomes. Exosomes act as a communicator between cells by transferring different cargos and microRNAs (miRNAs). Drug resistance is one of the...

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Autores principales: Guo, Qiao-ru, Wang, Hui, Yan, Ying-da, Liu, Yun, Su, Chao-yue, Chen, Hu-biao, Yan, Yan-yan, Adhikari, Rameshwar, Wu, Qiang, Zhang, Jian-ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154138/
https://www.ncbi.nlm.nih.gov/pubmed/32318350
http://dx.doi.org/10.3389/fonc.2020.00472
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author Guo, Qiao-ru
Wang, Hui
Yan, Ying-da
Liu, Yun
Su, Chao-yue
Chen, Hu-biao
Yan, Yan-yan
Adhikari, Rameshwar
Wu, Qiang
Zhang, Jian-ye
author_facet Guo, Qiao-ru
Wang, Hui
Yan, Ying-da
Liu, Yun
Su, Chao-yue
Chen, Hu-biao
Yan, Yan-yan
Adhikari, Rameshwar
Wu, Qiang
Zhang, Jian-ye
author_sort Guo, Qiao-ru
collection PubMed
description Exosomes affect the initiation and progression of cancers. In the tumor microenvironment, not only cancer cells, but also fibroblasts and immunocytes secrete exosomes. Exosomes act as a communicator between cells by transferring different cargos and microRNAs (miRNAs). Drug resistance is one of the critical factors affecting therapeutic effect in the course of cancer treatment. The currently known mechanisms of drug resistance include drug efflux, alterations in drug metabolism, DNA damage repair, alterations of energy programming, cancer stem cells and epigenetic changes. Many studies have shown that miRNA carried by exosomes is closely associated with the development of drug resistance mediated by the above-mentioned mechanisms. This review article will discuss how exosomal miRNAs regulate the drug resistance.
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spelling pubmed-71541382020-04-21 The Role of Exosomal microRNA in Cancer Drug Resistance Guo, Qiao-ru Wang, Hui Yan, Ying-da Liu, Yun Su, Chao-yue Chen, Hu-biao Yan, Yan-yan Adhikari, Rameshwar Wu, Qiang Zhang, Jian-ye Front Oncol Oncology Exosomes affect the initiation and progression of cancers. In the tumor microenvironment, not only cancer cells, but also fibroblasts and immunocytes secrete exosomes. Exosomes act as a communicator between cells by transferring different cargos and microRNAs (miRNAs). Drug resistance is one of the critical factors affecting therapeutic effect in the course of cancer treatment. The currently known mechanisms of drug resistance include drug efflux, alterations in drug metabolism, DNA damage repair, alterations of energy programming, cancer stem cells and epigenetic changes. Many studies have shown that miRNA carried by exosomes is closely associated with the development of drug resistance mediated by the above-mentioned mechanisms. This review article will discuss how exosomal miRNAs regulate the drug resistance. Frontiers Media S.A. 2020-04-07 /pmc/articles/PMC7154138/ /pubmed/32318350 http://dx.doi.org/10.3389/fonc.2020.00472 Text en Copyright © 2020 Guo, Wang, Yan, Liu, Su, Chen, Yan, Adhikari, Wu and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Guo, Qiao-ru
Wang, Hui
Yan, Ying-da
Liu, Yun
Su, Chao-yue
Chen, Hu-biao
Yan, Yan-yan
Adhikari, Rameshwar
Wu, Qiang
Zhang, Jian-ye
The Role of Exosomal microRNA in Cancer Drug Resistance
title The Role of Exosomal microRNA in Cancer Drug Resistance
title_full The Role of Exosomal microRNA in Cancer Drug Resistance
title_fullStr The Role of Exosomal microRNA in Cancer Drug Resistance
title_full_unstemmed The Role of Exosomal microRNA in Cancer Drug Resistance
title_short The Role of Exosomal microRNA in Cancer Drug Resistance
title_sort role of exosomal microrna in cancer drug resistance
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154138/
https://www.ncbi.nlm.nih.gov/pubmed/32318350
http://dx.doi.org/10.3389/fonc.2020.00472
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