Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar

Myeloproliferative neoplasms are a diversified group of diseases of the hematopoietic stem cell, such as essential thrombocythemia (ET) and polycythemia vera. They are mainly caused by mutations in the following genes: JAK2, CALR, and MPL. All carry an increased risk to transform into acute leukemia...

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Autores principales: Abu-Tineh, Mohammad, Kassem, Nancy, Abdulla, Mohammad Abdul-Jaber, Ismail, Omar Mohammad, Ghasoub, Rola, Aldapt, Mahmood B., Yassin, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154247/
https://www.ncbi.nlm.nih.gov/pubmed/32308601
http://dx.doi.org/10.1159/000506447
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author Abu-Tineh, Mohammad
Kassem, Nancy
Abdulla, Mohammad Abdul-Jaber
Ismail, Omar Mohammad
Ghasoub, Rola
Aldapt, Mahmood B.
Yassin, Mohamed A.
author_facet Abu-Tineh, Mohammad
Kassem, Nancy
Abdulla, Mohammad Abdul-Jaber
Ismail, Omar Mohammad
Ghasoub, Rola
Aldapt, Mahmood B.
Yassin, Mohamed A.
author_sort Abu-Tineh, Mohammad
collection PubMed
description Myeloproliferative neoplasms are a diversified group of diseases of the hematopoietic stem cell, such as essential thrombocythemia (ET) and polycythemia vera. They are mainly caused by mutations in the following genes: JAK2, CALR, and MPL. All carry an increased risk to transform into acute leukemia or chronic myelogenous leukemia along with thrombosis and hemorrhagic complications. Treatment of such disorders during pregnancy is a challenging footstep, given the high risk of complications for both the mother and the fetus. Here, we report about two pregnant females with ET that has been treated with pegylated interferon alpha with safe and effective outcome.
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spelling pubmed-71542472020-04-19 Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar Abu-Tineh, Mohammad Kassem, Nancy Abdulla, Mohammad Abdul-Jaber Ismail, Omar Mohammad Ghasoub, Rola Aldapt, Mahmood B. Yassin, Mohamed A. Case Rep Oncol Case Report Myeloproliferative neoplasms are a diversified group of diseases of the hematopoietic stem cell, such as essential thrombocythemia (ET) and polycythemia vera. They are mainly caused by mutations in the following genes: JAK2, CALR, and MPL. All carry an increased risk to transform into acute leukemia or chronic myelogenous leukemia along with thrombosis and hemorrhagic complications. Treatment of such disorders during pregnancy is a challenging footstep, given the high risk of complications for both the mother and the fetus. Here, we report about two pregnant females with ET that has been treated with pegylated interferon alpha with safe and effective outcome. S. Karger AG 2020-03-26 /pmc/articles/PMC7154247/ /pubmed/32308601 http://dx.doi.org/10.1159/000506447 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Abu-Tineh, Mohammad
Kassem, Nancy
Abdulla, Mohammad Abdul-Jaber
Ismail, Omar Mohammad
Ghasoub, Rola
Aldapt, Mahmood B.
Yassin, Mohamed A.
Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar
title Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar
title_full Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar
title_fullStr Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar
title_full_unstemmed Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar
title_short Outcome of Pregnancy in the Era of Pegylated Interferon Alpha 2a in Females with Essential Thrombocythemia: An Experience from Qatar
title_sort outcome of pregnancy in the era of pegylated interferon alpha 2a in females with essential thrombocythemia: an experience from qatar
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154247/
https://www.ncbi.nlm.nih.gov/pubmed/32308601
http://dx.doi.org/10.1159/000506447
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