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A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy

A 42-year-old woman with locally advanced luminal breast cancer was referred to our hospital. Ultrasonography showed marked skin thickening with obscured breast mass. Positron emission tomography showed bilateral swelling in the axillar, parasternal, and supraclavicular lymph nodes in addition to th...

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Detalles Bibliográficos
Autores principales: Tomita, Masafumi, Oura, Shoji, Makimoto, Shinichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154267/
https://www.ncbi.nlm.nih.gov/pubmed/32308587
http://dx.doi.org/10.1159/000506195
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author Tomita, Masafumi
Oura, Shoji
Makimoto, Shinichiro
author_facet Tomita, Masafumi
Oura, Shoji
Makimoto, Shinichiro
author_sort Tomita, Masafumi
collection PubMed
description A 42-year-old woman with locally advanced luminal breast cancer was referred to our hospital. Ultrasonography showed marked skin thickening with obscured breast mass. Positron emission tomography showed bilateral swelling in the axillar, parasternal, and supraclavicular lymph nodes in addition to the primary breast cancer. Following the patient's request, we treated her with primary bevacizumab-containing chemotherapy followed by radiotherapy to the breast due to the histologically proven widely spreading cancer remnants in the skin after chemotherapy. Thereafter, the patient underwent mastectomy and axillary dissection with a vertical rectus abdominis musculo-cutaneous flap to cover the skin defect. Pathological examination showed no viable cancer cells both in the breast and lymph nodes but imperceptible cytokeratin AE1 + 3-positive cells in the skin. Although wound healing needed 3 months due to the influence of preoperative radiotherapy, the patient has been well on endocrine therapy without any recurrence for more than 7 years.
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spelling pubmed-71542672020-04-19 A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy Tomita, Masafumi Oura, Shoji Makimoto, Shinichiro Case Rep Oncol Case Report A 42-year-old woman with locally advanced luminal breast cancer was referred to our hospital. Ultrasonography showed marked skin thickening with obscured breast mass. Positron emission tomography showed bilateral swelling in the axillar, parasternal, and supraclavicular lymph nodes in addition to the primary breast cancer. Following the patient's request, we treated her with primary bevacizumab-containing chemotherapy followed by radiotherapy to the breast due to the histologically proven widely spreading cancer remnants in the skin after chemotherapy. Thereafter, the patient underwent mastectomy and axillary dissection with a vertical rectus abdominis musculo-cutaneous flap to cover the skin defect. Pathological examination showed no viable cancer cells both in the breast and lymph nodes but imperceptible cytokeratin AE1 + 3-positive cells in the skin. Although wound healing needed 3 months due to the influence of preoperative radiotherapy, the patient has been well on endocrine therapy without any recurrence for more than 7 years. S. Karger AG 2020-03-24 /pmc/articles/PMC7154267/ /pubmed/32308587 http://dx.doi.org/10.1159/000506195 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Tomita, Masafumi
Oura, Shoji
Makimoto, Shinichiro
A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy
title A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy
title_full A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy
title_fullStr A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy
title_full_unstemmed A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy
title_short A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy
title_sort case of locally advanced breast cancer successfully treated with multidisciplinary therapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154267/
https://www.ncbi.nlm.nih.gov/pubmed/32308587
http://dx.doi.org/10.1159/000506195
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