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A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy
A 42-year-old woman with locally advanced luminal breast cancer was referred to our hospital. Ultrasonography showed marked skin thickening with obscured breast mass. Positron emission tomography showed bilateral swelling in the axillar, parasternal, and supraclavicular lymph nodes in addition to th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
S. Karger AG
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154267/ https://www.ncbi.nlm.nih.gov/pubmed/32308587 http://dx.doi.org/10.1159/000506195 |
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author | Tomita, Masafumi Oura, Shoji Makimoto, Shinichiro |
author_facet | Tomita, Masafumi Oura, Shoji Makimoto, Shinichiro |
author_sort | Tomita, Masafumi |
collection | PubMed |
description | A 42-year-old woman with locally advanced luminal breast cancer was referred to our hospital. Ultrasonography showed marked skin thickening with obscured breast mass. Positron emission tomography showed bilateral swelling in the axillar, parasternal, and supraclavicular lymph nodes in addition to the primary breast cancer. Following the patient's request, we treated her with primary bevacizumab-containing chemotherapy followed by radiotherapy to the breast due to the histologically proven widely spreading cancer remnants in the skin after chemotherapy. Thereafter, the patient underwent mastectomy and axillary dissection with a vertical rectus abdominis musculo-cutaneous flap to cover the skin defect. Pathological examination showed no viable cancer cells both in the breast and lymph nodes but imperceptible cytokeratin AE1 + 3-positive cells in the skin. Although wound healing needed 3 months due to the influence of preoperative radiotherapy, the patient has been well on endocrine therapy without any recurrence for more than 7 years. |
format | Online Article Text |
id | pubmed-7154267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-71542672020-04-19 A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy Tomita, Masafumi Oura, Shoji Makimoto, Shinichiro Case Rep Oncol Case Report A 42-year-old woman with locally advanced luminal breast cancer was referred to our hospital. Ultrasonography showed marked skin thickening with obscured breast mass. Positron emission tomography showed bilateral swelling in the axillar, parasternal, and supraclavicular lymph nodes in addition to the primary breast cancer. Following the patient's request, we treated her with primary bevacizumab-containing chemotherapy followed by radiotherapy to the breast due to the histologically proven widely spreading cancer remnants in the skin after chemotherapy. Thereafter, the patient underwent mastectomy and axillary dissection with a vertical rectus abdominis musculo-cutaneous flap to cover the skin defect. Pathological examination showed no viable cancer cells both in the breast and lymph nodes but imperceptible cytokeratin AE1 + 3-positive cells in the skin. Although wound healing needed 3 months due to the influence of preoperative radiotherapy, the patient has been well on endocrine therapy without any recurrence for more than 7 years. S. Karger AG 2020-03-24 /pmc/articles/PMC7154267/ /pubmed/32308587 http://dx.doi.org/10.1159/000506195 Text en Copyright © 2020 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission. |
spellingShingle | Case Report Tomita, Masafumi Oura, Shoji Makimoto, Shinichiro A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy |
title | A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy |
title_full | A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy |
title_fullStr | A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy |
title_full_unstemmed | A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy |
title_short | A Case of Locally Advanced Breast Cancer Successfully Treated with Multidisciplinary Therapy |
title_sort | case of locally advanced breast cancer successfully treated with multidisciplinary therapy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154267/ https://www.ncbi.nlm.nih.gov/pubmed/32308587 http://dx.doi.org/10.1159/000506195 |
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