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Prevalence of bone mineral density loss and potential risk factors for osteopenia and osteoporosis in rheumatic patients in China: logistic regression and random forest analysis

BACKGROUND: The objective of this study was to explore the prevalence of change in bone mineral density (BMD) and the potential risk factors for osteopenia and osteoporosis in rheumatic patients. METHODS: An analytical cross-sectional study design was carried out. For this study, one thousand and se...

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Autores principales: Zhang, Xi, Dai, Zonglin, Lau, Eric H. Y., Cui, Chunping, Lin, He, Qi, Jun, Ni, Weifeng, Zhao, Like, Lv, Qing, Gu, Jieruo, Lin, Zhiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154412/
https://www.ncbi.nlm.nih.gov/pubmed/32309373
http://dx.doi.org/10.21037/atm.2020.01.08
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author Zhang, Xi
Dai, Zonglin
Lau, Eric H. Y.
Cui, Chunping
Lin, He
Qi, Jun
Ni, Weifeng
Zhao, Like
Lv, Qing
Gu, Jieruo
Lin, Zhiming
author_facet Zhang, Xi
Dai, Zonglin
Lau, Eric H. Y.
Cui, Chunping
Lin, He
Qi, Jun
Ni, Weifeng
Zhao, Like
Lv, Qing
Gu, Jieruo
Lin, Zhiming
author_sort Zhang, Xi
collection PubMed
description BACKGROUND: The objective of this study was to explore the prevalence of change in bone mineral density (BMD) and the potential risk factors for osteopenia and osteoporosis in rheumatic patients. METHODS: An analytical cross-sectional study design was carried out. For this study, one thousand and seven rheumatic patients were recruited and further accepted for data collection and blood and BMD tests. The potential risk factors for osteopenia and osteoporosis in rheumatic patients were further analyzed by using both logistic regression analysis and random forest (RF) analysis. RESULTS: 41.1% of the male patients aged 50 years or above and 50.8% of postmenopausal patients were osteoporotic in their lumbar spine. Among these patients, the prevalence of osteoporosis in the femoral neck and total hip was 19.4% and 8.9% in men, and 27.6% and 16.5% in women respectively, while more than half of the rheumatic patients had osteopenia in the femoral neck and total hip. For men younger than 50 years and premenopausal women, BMD were lower than the health population in the femoral neck (16.5% and 18.3% respectively) and the total hip (17.4% and 10.4% respectively). Older age, body mass index (BMI) <18.5 kg/m(2), female sex and glucocorticoid use were associated with lower BMD in the lumbar spine, femoral neck, and total hip of patients. In RF analysis, age was ranked as the most important factor for osteopenia in the lumbar spine, femoral neck, and total hip of patients, followed by glucocorticoid use and BMI. CONCLUSIONS: More interventions should be given to osteopenia patients because of the higher prevalence when compared with osteoporosis patients. Older age, BMI <18.5 kg/m(2), female sex and glucocorticoid use were associated with lower BMD in rheumatic patients. The results from the logistic regression can be supplemented by random forest analysis.
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spelling pubmed-71544122020-04-17 Prevalence of bone mineral density loss and potential risk factors for osteopenia and osteoporosis in rheumatic patients in China: logistic regression and random forest analysis Zhang, Xi Dai, Zonglin Lau, Eric H. Y. Cui, Chunping Lin, He Qi, Jun Ni, Weifeng Zhao, Like Lv, Qing Gu, Jieruo Lin, Zhiming Ann Transl Med Original Article BACKGROUND: The objective of this study was to explore the prevalence of change in bone mineral density (BMD) and the potential risk factors for osteopenia and osteoporosis in rheumatic patients. METHODS: An analytical cross-sectional study design was carried out. For this study, one thousand and seven rheumatic patients were recruited and further accepted for data collection and blood and BMD tests. The potential risk factors for osteopenia and osteoporosis in rheumatic patients were further analyzed by using both logistic regression analysis and random forest (RF) analysis. RESULTS: 41.1% of the male patients aged 50 years or above and 50.8% of postmenopausal patients were osteoporotic in their lumbar spine. Among these patients, the prevalence of osteoporosis in the femoral neck and total hip was 19.4% and 8.9% in men, and 27.6% and 16.5% in women respectively, while more than half of the rheumatic patients had osteopenia in the femoral neck and total hip. For men younger than 50 years and premenopausal women, BMD were lower than the health population in the femoral neck (16.5% and 18.3% respectively) and the total hip (17.4% and 10.4% respectively). Older age, body mass index (BMI) <18.5 kg/m(2), female sex and glucocorticoid use were associated with lower BMD in the lumbar spine, femoral neck, and total hip of patients. In RF analysis, age was ranked as the most important factor for osteopenia in the lumbar spine, femoral neck, and total hip of patients, followed by glucocorticoid use and BMI. CONCLUSIONS: More interventions should be given to osteopenia patients because of the higher prevalence when compared with osteoporosis patients. Older age, BMI <18.5 kg/m(2), female sex and glucocorticoid use were associated with lower BMD in rheumatic patients. The results from the logistic regression can be supplemented by random forest analysis. AME Publishing Company 2020-03 /pmc/articles/PMC7154412/ /pubmed/32309373 http://dx.doi.org/10.21037/atm.2020.01.08 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Zhang, Xi
Dai, Zonglin
Lau, Eric H. Y.
Cui, Chunping
Lin, He
Qi, Jun
Ni, Weifeng
Zhao, Like
Lv, Qing
Gu, Jieruo
Lin, Zhiming
Prevalence of bone mineral density loss and potential risk factors for osteopenia and osteoporosis in rheumatic patients in China: logistic regression and random forest analysis
title Prevalence of bone mineral density loss and potential risk factors for osteopenia and osteoporosis in rheumatic patients in China: logistic regression and random forest analysis
title_full Prevalence of bone mineral density loss and potential risk factors for osteopenia and osteoporosis in rheumatic patients in China: logistic regression and random forest analysis
title_fullStr Prevalence of bone mineral density loss and potential risk factors for osteopenia and osteoporosis in rheumatic patients in China: logistic regression and random forest analysis
title_full_unstemmed Prevalence of bone mineral density loss and potential risk factors for osteopenia and osteoporosis in rheumatic patients in China: logistic regression and random forest analysis
title_short Prevalence of bone mineral density loss and potential risk factors for osteopenia and osteoporosis in rheumatic patients in China: logistic regression and random forest analysis
title_sort prevalence of bone mineral density loss and potential risk factors for osteopenia and osteoporosis in rheumatic patients in china: logistic regression and random forest analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154412/
https://www.ncbi.nlm.nih.gov/pubmed/32309373
http://dx.doi.org/10.21037/atm.2020.01.08
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