Left ventricular response in the transition from hypertrophy to failure recapitulates distinct roles of Akt, β-arrestin-2, and CaMKII in mice with aortic regurgitation

BACKGROUND: Although aortic regurgitation (AR) is a clinically important condition that is becoming increasingly common, few relevant murine models and mechanistic studies exist for this condition. In this study, we attempted to delineate the pathological and molecular changes and address the roles...

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Detalles Bibliográficos
Autores principales: Wu, Jian, You, Jieyun, Wang, Xiaoyan, Wang, Shijun, Huang, Jiayuan, Xie, Qihai, Gong, Baoyong, Ding, Zhiwen, Ye, Yong, Wang, Cong, Kang, Le, Xu, Ran, Li, Yang, Chen, Ruizhen, Sun, Aijun, Yang, Xiangdong, Jiang, Hong, Yang, Fenghua, Backx, Peter H., Ge, Junbo, Zou, Yunzeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154424/
https://www.ncbi.nlm.nih.gov/pubmed/32309366
http://dx.doi.org/10.21037/atm.2020.01.51

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