Cargando…

Anticancer Effect of Radix Astragali on Cholangiocarcinoma In Vitro and Its Mechanism via Network Pharmacology

BACKGROUND: This study used network pharmacology method and cell model to assess the effects of Radix Astragali (RA) on cholangiocarcinoma (CCA) and to predict core targets and molecular mechanisms. MATERIAL/METHODS: We performed an in vitro study to assess the effect of RA on CCA using CCK8 assay,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yixiu, Dong, Bingzi, Xue, Weijie, Feng, Yujie, Yang, Chenyu, Liu, Peng, Cao, Jingyu, Zhu, Chengzhan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2020
Materias:	Lab/In Vitro Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154565/ https://www.ncbi.nlm.nih.gov/pubmed/32246704 http://dx.doi.org/10.12659/MSM.921162

Ejemplares similares

Radix Tetrastigma Hemsleyani Flavone Suppresses Cutaneous Squamous Cell Carcinoma A431 Cells via Proteasome Inhibition
por: Zhong, Liangrui, et al.
Publicado: (2019)

A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine
por: Guo, Zhenzhen, et al.
Publicado: (2019)

Effect of Mir-122 on Human Cholangiocarcinoma Proliferation, Invasion, and Apoptosis Through P53 Expression
por: Wu, Cuiping, et al.
Publicado: (2016)

Anticancer Effect and Apoptosis Induction of Gambogic Acid in Human Leukemia Cell Line K562 In Vitro
por: Chen, Jinhao, et al.
Publicado: (2015)

Downregulated Expression of Tropomyosin 1 in Intrahepatic Cholangiocarcinoma: A Predictor of Recurrence and Prognosis
por: Chen, Yan, et al.
Publicado: (2018)

Fascin Induces Epithelial-Mesenchymal Transition of Cholangiocarcinoma Cells by Regulating Wnt/β-Catenin Signaling
por: Mao, Xianhai, et al.
Publicado: (2016)

The TTYH3/MK5 Positive Feedback Loop regulates Tumor Progression via GSK3-β/β-catenin signaling in HCC
por: Wang, Yixiu, et al.
Publicado: (2022)

Overexpression of Tripartite Motif Conaining 55 (TRIM55) Inhibits Migration and Invasion of Hepatocellular Carcinoma (HCC) Cells via Epithelial-Mesenchymal Transition and Matrix Metalloproteinase-2 (MMP2)
por: Li, Xinyu, et al.
Publicado: (2019)

Escherichia Coli PagP Enzyme-Based De Novo Design and In Vitro Activity of Antibacterial Peptide LL-37
por: Yang, Hao, et al.
Publicado: (2017)

Network Pharmacology to Identify the Pharmacological Mechanisms of a Traditional Chinese Medicine Derived from Trachelospermum jasminoides in Patients with Rheumatoid Arthritis
por: Jiang, Tao, et al.
Publicado: (2020)

Study on the Mechanism of Radix Astragali against Renal Aging Based on Network Pharmacology
por: Zhang, Ziyuan, et al.
Publicado: (2022)

Anticancer Effects of Gingerol in Retinoblastoma Cancer Cells (RB355 Cell Line) Are Mediated via Apoptosis Induction, Cell Cycle Arrest and Upregulation of PI3K/Akt Signaling Pathway
por: Meng, Bo, et al.
Publicado: (2018)

Neutrophil Gelatinase-Associated Lipocalin Attenuates Ischemia/Reperfusion Injury in an In Vitro Model via Autophagy Activation
por: Yan, Cai, et al.
Publicado: (2018)

Cucurbitacin B Inhibits the Hippo-YAP Signaling Pathway and Exerts Anticancer Activity in Colorectal Cancer Cells
por: Chai, Yanting, et al.
Publicado: (2018)

A Network Pharmacology Analysis to Explore the Effect of Astragali Radix-Radix Angelica Sinensis on Traumatic Brain Injury
por: Xie, Genggeng, et al.
Publicado: (2018)

The Effects of Plumbagin on Pancreatic Cancer: A Mechanistic Network Pharmacology Approach
por: Pan, Qijin, et al.
Publicado: (2019)

Evaluation of the Pharmaceutical Properties and Value of Astragali Radix
por: Gong, Amy G. W., et al.
Publicado: (2018)

Comparison of the Immunoregulatory Function of Different Constituents in Radix Astragali and Radix Hedysari
por: Liu, Jing, et al.
Publicado: (2010)

Mechanisms of Paeonia lactiflora in Treatment of Ulcerative Colitis: A Network Pharmacological Study
por: Zhang, Yin, et al.
Publicado: (2019)

Bidirectional Regulatory Effects of Dexmedetomidine on Porcine Coronary Tone In Vitro
por: Zhou, Shu-Zhi, et al.
Publicado: (2017)

Anticancer Effects of Paris Saponins by Apoptosis and PI3K/AKT Pathway in Gefitinib-Resistant Non-Small Cell Lung Cancer
por: Zhu, Xinhai, et al.
Publicado: (2016)

Predicting the anti-inflammatory mechanism of Radix Astragali using network pharmacology and molecular docking
por: Ren, Jianwei, et al.
Publicado: (2023)

Ursolic Acid Exhibits Potent Anticancer Effects in Human Metastatic Melanoma Cancer Cells (SK-MEL-24) via Apoptosis Induction, Inhibition of Cell Migration and Invasion, Cell Cycle Arrest, and Inhibition of Mitogen-Activated Protein Kinase (MAPK)/ERK Signaling Pathway
por: Liu, Pengcheng, et al.
Publicado: (2019)

A Network Pharmacology Approach to Determine the Active Components and Potential Targets of Curculigo Orchioides in the Treatment of Osteoporosis
por: Wang, Nani, et al.
Publicado: (2017)

A Network Pharmacology Approach to Estimate the Active Ingredients and Potential Targets of Cuscutae semen in the Treatment of Osteoporosis
por: Dai, Weiran, et al.
Publicado: (2020)

Network Pharmacology–Based Prediction and Pharmacological Validation of Effects of Astragali Radix on Acetaminophen-Induced Liver Injury
por: Peng, Yuan, et al.
Publicado: (2022)

MicroRNA-184 Promotes Proliferation and Inhibits Apoptosis in HaCaT Cells: An In Vitro Study
por: Bi, Xiaodong, et al.
Publicado: (2016)

Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro
por: Yang, Yu, et al.
Publicado: (2019)

Berberine Restricts Coxsackievirus B Type 3 Replication via Inhibition of c-Jun N-Terminal Kinase (JNK) and p38 MAPK Activation In Vitro
por: Dai, Qian, et al.
Publicado: (2017)

Anticancer Activity of Phloretin Against Human Gastric Cancer Cell Lines Involves Apoptosis, Cell Cycle Arrest, and Inhibition of Cell Invasion and JNK Signalling Pathway
por: Xu, Min, et al.
Publicado: (2018)

Antioxidation of Cerium Oxide Nanoparticles to Several Series of Oxidative Damage Related to Type II Diabetes Mellitus In Vitro
por: Zhai, Jing-hui, et al.
Publicado: (2016)

Genotoxicity Evaluation of an Ethanol Extract Mixture of Astragali Radix and Salviae miltiorrhizae Radix
por: Lee, Jin-Seok, et al.
Publicado: (2018)

Mechanism of Radix Astragali and Radix Salviae Miltiorrhizae Ameliorates Hypertensive Renal Damage
por: Hou, Guangjian, et al.
Publicado: (2021)

Upregulation of CXCR7 Is Associated with Poor Prognosis of Prostate Cancer
por: Yang, Jihua, et al.
Publicado: (2018)

Anticancer Activity of Mukonal Against Human Laryngeal Cancer Cells Involves Apoptosis, Cell Cycle Arrest, and Inhibition of PI3K/AKT and MEK/ERK Signalling Pathways
por: Li, Liu, et al.
Publicado: (2018)

The Effect of Overexpression of the Enhancer of Zeste Homolog 1 (EZH1) Gene on Aristolochic Acid-Induced Injury in HK-2 Human Kidney Proximal Tubule Cells In Vitro
por: Wang, Liping, et al.
Publicado: (2019)

Identification of Apolipoprotein C-I Peptides as a Potential Biomarker and its Biological Roles in Breast Cancer
por: Sun, Yadong, et al.
Publicado: (2016)

Androgen Receptor Is Inactivated and Degraded in Bladder Cancer Cells by Phenyl Glucosamine via miR-449a Restoration
por: Guo, Ju, et al.
Publicado: (2018)

Underexpression of CACNA1C Caused by Overexpression of microRNA-29a Underlies the Pathogenesis of Atrial Fibrillation
por: Zhao, Yujie, et al.
Publicado: (2016)

Anticancer Activity of Metformin, an Antidiabetic Drug, Against Ovarian Cancer Cells Involves Inhibition of Cysteine-Rich 61 (Cyr61)/Akt/Mammalian Target of Rapamycin (mTOR) Signaling Pathway
por: Zhang, Fengli, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_trfrdfhravdbh9l3gohge1qpa0