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Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder

Research into insomnia disorder has pointed to large‐scale brain network dysfunctions. Dynamic functional connectivity is instrumental to cognitive functions but has not been investigated in insomnia disorder. This study assessed between‐network functional connectivity strength and variability in pa...

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Autores principales: Wei, Yishul, Leerssen, Jeanne, Wassing, Rick, Stoffers, Diederick, Perrier, Joy, Van Someren, Eus J. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154624/
https://www.ncbi.nlm.nih.gov/pubmed/32164035
http://dx.doi.org/10.1111/jsr.12953
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author Wei, Yishul
Leerssen, Jeanne
Wassing, Rick
Stoffers, Diederick
Perrier, Joy
Van Someren, Eus J. W.
author_facet Wei, Yishul
Leerssen, Jeanne
Wassing, Rick
Stoffers, Diederick
Perrier, Joy
Van Someren, Eus J. W.
author_sort Wei, Yishul
collection PubMed
description Research into insomnia disorder has pointed to large‐scale brain network dysfunctions. Dynamic functional connectivity is instrumental to cognitive functions but has not been investigated in insomnia disorder. This study assessed between‐network functional connectivity strength and variability in patients with insomnia disorder as compared with matched controls without sleep complaints. Twelve‐minute resting‐state functional magnetic resonance images and T1‐weighed images were acquired in 65 people diagnosed with insomnia disorder (21–69 years, 48 female) and 65 matched controls without sleep complaints (22–70 years, 42 female). Pairwise correlations between the activity time series of 14 resting‐state networks and temporal variability of the correlations were compared between cases and controls. After false discovery rate correction for multiple comparisons, people with insomnia disorder and controls did not differ significantly in terms of mean between‐network functional connectivity strength; people with insomnia disorder did, however, show less functional connectivity variability between the anterior salience network and the left executive‐control network. The finding suggests less flexible interactions between the networks during the resting state in people with insomnia disorder.
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spelling pubmed-71546242020-04-14 Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder Wei, Yishul Leerssen, Jeanne Wassing, Rick Stoffers, Diederick Perrier, Joy Van Someren, Eus J. W. J Sleep Res Insomnia Research into insomnia disorder has pointed to large‐scale brain network dysfunctions. Dynamic functional connectivity is instrumental to cognitive functions but has not been investigated in insomnia disorder. This study assessed between‐network functional connectivity strength and variability in patients with insomnia disorder as compared with matched controls without sleep complaints. Twelve‐minute resting‐state functional magnetic resonance images and T1‐weighed images were acquired in 65 people diagnosed with insomnia disorder (21–69 years, 48 female) and 65 matched controls without sleep complaints (22–70 years, 42 female). Pairwise correlations between the activity time series of 14 resting‐state networks and temporal variability of the correlations were compared between cases and controls. After false discovery rate correction for multiple comparisons, people with insomnia disorder and controls did not differ significantly in terms of mean between‐network functional connectivity strength; people with insomnia disorder did, however, show less functional connectivity variability between the anterior salience network and the left executive‐control network. The finding suggests less flexible interactions between the networks during the resting state in people with insomnia disorder. John Wiley and Sons Inc. 2019-12-03 2020-04 /pmc/articles/PMC7154624/ /pubmed/32164035 http://dx.doi.org/10.1111/jsr.12953 Text en © 2019 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Insomnia
Wei, Yishul
Leerssen, Jeanne
Wassing, Rick
Stoffers, Diederick
Perrier, Joy
Van Someren, Eus J. W.
Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder
title Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder
title_full Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder
title_fullStr Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder
title_full_unstemmed Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder
title_short Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder
title_sort reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder
topic Insomnia
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154624/
https://www.ncbi.nlm.nih.gov/pubmed/32164035
http://dx.doi.org/10.1111/jsr.12953
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