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Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to S‐Equol and Its Consequences for ERα Activation

SCOPE: To predict gut microbial metabolism of xenobiotics and the resulting plasma concentrations of metabolites formed, an in vitro–in silico‐based testing strategy is developed using the isoflavone daidzein and its gut microbial metabolite S‐equol as model compounds. METHODS AND RESULTS: Anaerobic...

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Detalles Bibliográficos
Autores principales:	Wang, Qianrui, Spenkelink, Bert, Boonpawa, Rungnapa, Rietjens, Ivonne M. C. M., Beekmann, Karsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154660/ https://www.ncbi.nlm.nih.gov/pubmed/32027771 http://dx.doi.org/10.1002/mnfr.201900912

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