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Structural Insight into IAPP‐Derived Amyloid Inhibitors and Their Mechanism of Action

Designed peptides derived from the islet amyloid polypeptide (IAPP) cross‐amyloid interaction surface with Aβ (termed interaction surface mimics or ISMs) have been shown to be highly potent inhibitors of Aβ amyloid self‐assembly. However, the molecular mechanism of their function is not well underst...

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Detalles Bibliográficos
Autores principales:	Niu, Zheng, Prade, Elke, Malideli, Eleni, Hille, Kathleen, Jussupow, Alexander, Mideksa, Yonatan G., Yan, Li‐Mei, Qian, Chen, Fleisch, Markus, Messias, Ana C., Sarkar, Riddhiman, Sattler, Michael, Lamb, Don C., Feige, Matthias J., Camilloni, Carlo, Kapurniotu, Aphrodite, Reif, Bernd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154662/ https://www.ncbi.nlm.nih.gov/pubmed/31863711 http://dx.doi.org/10.1002/anie.201914559

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