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Extended experience with a non‐cytotoxic DNMT1‐targeting regimen of decitabine to treat myeloid malignancies

The nucleoside analogue decitabine can deplete the epigenetic regulator DNA methyltransferase 1 (DNMT1), an effect that occurs, and is saturated at, low concentrations/doses. A reason to pursue this molecular‐targeted effect instead of the DNA damage/cytotoxicity produced with high concentrations/do...

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Detalles Bibliográficos
Autores principales:	Awada, Hassan, Mahfouz, Reda Z., Kishtagari, Ashwin, Kuzmanovic, Teodora, Durrani, Jibran, Kerr, Cassandra M., Patel, Bhumika J., Visconte, Valeria, Radivoyevitch, Tomas, Lichtin, Alan, Carraway, Hetty E., Maciejewski, Jaroslaw P., Saunthararajah, Yogen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Haematological Malignancy – Clinical
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154732/ https://www.ncbi.nlm.nih.gov/pubmed/31736067 http://dx.doi.org/10.1111/bjh.16281

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