The Role of MicroRNAs in Regulatory T Cells

MicroRNAs are a class of conserved, 20 nt-23 nt long, noncoding small RNAs that inhibit expression of their respective target genes in different cell types. Regulatory T cells (Tregs) are a subpopulation of T cells that negatively regulate immune responses, which is essential to immune homeostasis....

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Detalles Bibliográficos
Autores principales: Liu, Chao, Li, Nannan, Liu, Guijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154970/
https://www.ncbi.nlm.nih.gov/pubmed/32322593
http://dx.doi.org/10.1155/2020/3232061
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author Liu, Chao
Li, Nannan
Liu, Guijian
author_facet Liu, Chao
Li, Nannan
Liu, Guijian
author_sort Liu, Chao
collection PubMed
description MicroRNAs are a class of conserved, 20 nt-23 nt long, noncoding small RNAs that inhibit expression of their respective target genes in different cell types. Regulatory T cells (Tregs) are a subpopulation of T cells that negatively regulate immune responses, which is essential to immune homeostasis. Recent studies have indicated that microRNAs play an important role in the proliferation, differentiation, and functions of Treg. Here, we review the recent progress in understanding the roles of microRNAs in Treg and their dysregulation in immune-related diseases. This ongoing research continues to expand the understanding of Treg regulation and the mechanisms of immune disorders.
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spelling pubmed-71549702020-04-22 The Role of MicroRNAs in Regulatory T Cells Liu, Chao Li, Nannan Liu, Guijian J Immunol Res Review Article MicroRNAs are a class of conserved, 20 nt-23 nt long, noncoding small RNAs that inhibit expression of their respective target genes in different cell types. Regulatory T cells (Tregs) are a subpopulation of T cells that negatively regulate immune responses, which is essential to immune homeostasis. Recent studies have indicated that microRNAs play an important role in the proliferation, differentiation, and functions of Treg. Here, we review the recent progress in understanding the roles of microRNAs in Treg and their dysregulation in immune-related diseases. This ongoing research continues to expand the understanding of Treg regulation and the mechanisms of immune disorders. Hindawi 2020-04-02 /pmc/articles/PMC7154970/ /pubmed/32322593 http://dx.doi.org/10.1155/2020/3232061 Text en Copyright © 2020 Chao Liu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Liu, Chao
Li, Nannan
Liu, Guijian
The Role of MicroRNAs in Regulatory T Cells
title The Role of MicroRNAs in Regulatory T Cells
title_full The Role of MicroRNAs in Regulatory T Cells
title_fullStr The Role of MicroRNAs in Regulatory T Cells
title_full_unstemmed The Role of MicroRNAs in Regulatory T Cells
title_short The Role of MicroRNAs in Regulatory T Cells
title_sort role of micrornas in regulatory t cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154970/
https://www.ncbi.nlm.nih.gov/pubmed/32322593
http://dx.doi.org/10.1155/2020/3232061
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