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A degradatory fate for CCR4 suggests a primary role in Th2 inflammation

CCR4 is the sole receptor for the chemokines CCL22 and CCL17. Clinical studies of asthmatic airways have shown levels of both ligands and CCR4(+) Th2 cells to be elevated, suggestive of a role in disease. Consequently, CCR4 has aroused much interest as a potential therapeutic target and an understan...

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Detalles Bibliográficos
Autores principales:	Anderson, Caroline A., Patel, Pallavi, Viney, Jonathan M., Phillips, Rhian M., Solari, Roberto, Pease, James E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Receptors, Signal Transduction & Genes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155072/ https://www.ncbi.nlm.nih.gov/pubmed/32052476 http://dx.doi.org/10.1002/JLB.2A0120-089RR

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