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Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation

The hippocampal mossy fiber (MF) synapse has been implicated in the pathophysiology and treatment of psychiatric disorders. Alterations of dopaminergic and serotonergic modulations at this synapse are candidate mechanisms underlying antidepressant and other related treatments. However, these monoami...

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Autores principales: Kobayashi, Katsunori, Mikahara, Yasunori, Murata, Yuka, Morita, Daiki, Matsuura, Sumire, Segi-Nishida, Eri, Suzuki, Hidenori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155202/
https://www.ncbi.nlm.nih.gov/pubmed/32283526
http://dx.doi.org/10.1016/j.isci.2020.101025
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author Kobayashi, Katsunori
Mikahara, Yasunori
Murata, Yuka
Morita, Daiki
Matsuura, Sumire
Segi-Nishida, Eri
Suzuki, Hidenori
author_facet Kobayashi, Katsunori
Mikahara, Yasunori
Murata, Yuka
Morita, Daiki
Matsuura, Sumire
Segi-Nishida, Eri
Suzuki, Hidenori
author_sort Kobayashi, Katsunori
collection PubMed
description The hippocampal mossy fiber (MF) synapse has been implicated in the pathophysiology and treatment of psychiatric disorders. Alterations of dopaminergic and serotonergic modulations at this synapse are candidate mechanisms underlying antidepressant and other related treatments. However, these monoaminergic modulations share the intracellular signaling pathway at the MF synapse, which implies redundancy in their functions. We here show that endogenous monoamines can potentiate MF synaptic transmission in mouse hippocampal slices by activating the serotonin 5-HT(4) receptor. Dopamine receptors were not effectively activated by endogenous agonists, suggesting that the dopaminergic modulation is latent. Electroconvulsive treatment enhanced the 5-HT(4) receptor-mediated serotonergic synaptic potentiation specifically at the MF synapse, increased the hippocampal serotonin content, and produced an anxiolytic-like behavioral effect in a 5-HT(4) receptor-dependent manner. These results suggest that serotonin plays a predominant role in monoaminergic modulations at the MF synapse. Augmentation of this serotonergic modulation may mediate anxiolytic effects of electroconvulsive treatment.
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spelling pubmed-71552022020-04-17 Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation Kobayashi, Katsunori Mikahara, Yasunori Murata, Yuka Morita, Daiki Matsuura, Sumire Segi-Nishida, Eri Suzuki, Hidenori iScience Article The hippocampal mossy fiber (MF) synapse has been implicated in the pathophysiology and treatment of psychiatric disorders. Alterations of dopaminergic and serotonergic modulations at this synapse are candidate mechanisms underlying antidepressant and other related treatments. However, these monoaminergic modulations share the intracellular signaling pathway at the MF synapse, which implies redundancy in their functions. We here show that endogenous monoamines can potentiate MF synaptic transmission in mouse hippocampal slices by activating the serotonin 5-HT(4) receptor. Dopamine receptors were not effectively activated by endogenous agonists, suggesting that the dopaminergic modulation is latent. Electroconvulsive treatment enhanced the 5-HT(4) receptor-mediated serotonergic synaptic potentiation specifically at the MF synapse, increased the hippocampal serotonin content, and produced an anxiolytic-like behavioral effect in a 5-HT(4) receptor-dependent manner. These results suggest that serotonin plays a predominant role in monoaminergic modulations at the MF synapse. Augmentation of this serotonergic modulation may mediate anxiolytic effects of electroconvulsive treatment. Elsevier 2020-03-31 /pmc/articles/PMC7155202/ /pubmed/32283526 http://dx.doi.org/10.1016/j.isci.2020.101025 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kobayashi, Katsunori
Mikahara, Yasunori
Murata, Yuka
Morita, Daiki
Matsuura, Sumire
Segi-Nishida, Eri
Suzuki, Hidenori
Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation
title Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation
title_full Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation
title_fullStr Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation
title_full_unstemmed Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation
title_short Predominant Role of Serotonin at the Hippocampal Mossy Fiber Synapse with Redundant Monoaminergic Modulation
title_sort predominant role of serotonin at the hippocampal mossy fiber synapse with redundant monoaminergic modulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155202/
https://www.ncbi.nlm.nih.gov/pubmed/32283526
http://dx.doi.org/10.1016/j.isci.2020.101025
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