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Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression

DNA transfection is often the bottleneck of research and gene therapy practices. To explore the mechanism regulating transgene expression, we investigated the role of the cGAS-STING signaling pathway, which induces type-I interferons in response to DNA. We confirmed that deletion of cGAS enhances tr...

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Detalles Bibliográficos
Autores principales:	Fu, Yajuan, Fang, Yijun, Lin, Zhang, Yang, Lei, Zheng, Liqun, Hu, Hao, Yu, Tingting, Huang, Baoting, Chen, Suxing, Wang, Hanze, Xu, Shan, Bao, Wei, Chen, Qi, Sun, Lijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155207/ https://www.ncbi.nlm.nih.gov/pubmed/32283527 http://dx.doi.org/10.1016/j.isci.2020.101026

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