MCL-1 Inhibition by Selective BH3 Mimetics Disrupts Mitochondrial Dynamics Causing Loss of Viability and Functionality of Human Cardiomyocytes

MCL-1 is a well-characterized inhibitor of cell death that has also been shown to be a regulator of mitochondrial dynamics in human pluripotent stem cells. We used cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CMs) to uncover whether MCL-1 is crucial for cardiac function an...

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Detalles Bibliográficos
Autores principales: Rasmussen, Megan L., Taneja, Nilay, Neininger, Abigail C., Wang, Lili, Robertson, Gabriella L., Riffle, Stellan N., Shi, Linzheng, Knollmann, Bjorn C., Burnette, Dylan T., Gama, Vivian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155208/
https://www.ncbi.nlm.nih.gov/pubmed/32283523
http://dx.doi.org/10.1016/j.isci.2020.101015

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