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UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks

Chemical modifications and adducts at DNA double-strand break (DSB) ends must be cleaned before re-joining by non-homologous end-joining (NHEJ). MRE11 nuclease is essential for efficient removal of Topoisomerase II (TOP2)-DNA adducts from TOP2 poison-induced DSBs. However, mechanisms in MRE11 recrui...

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Detalles Bibliográficos
Autores principales:	Akagawa, Remi, Trinh, Hai Thanh, Saha, Liton Kumar, Tsuda, Masataka, Hirota, Kouji, Yamada, Shintaro, Shibata, Atsushi, Kanemaki, Masato T., Nakada, Shinichiro, Takeda, Shunichi, Sasanuma, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155233/ https://www.ncbi.nlm.nih.gov/pubmed/32283528 http://dx.doi.org/10.1016/j.isci.2020.101027

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