Cargando…
Measuring serum estradiol and progesterone one day prior to frozen embryo transfer improves live birth rates
BACKGROUND: Given no consensus in the literature, this study sought to determine if a protocol of measuring serum estradiol and progesterone the day prior to frozen embryo transfer (FET) improves likelihood of pregnancy and livebirth. METHODS: This was a retrospective time-series study of women unde...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155246/ https://www.ncbi.nlm.nih.gov/pubmed/32313664 http://dx.doi.org/10.1186/s40738-020-00075-2 |
_version_ | 1783521992567160832 |
---|---|
author | Alur-Gupta, Snigdha Hopeman, Margaret Berger, Dara S. Barnhart, Kurt T. Senapati, Suneeta Gracia, Clarisa |
author_facet | Alur-Gupta, Snigdha Hopeman, Margaret Berger, Dara S. Barnhart, Kurt T. Senapati, Suneeta Gracia, Clarisa |
author_sort | Alur-Gupta, Snigdha |
collection | PubMed |
description | BACKGROUND: Given no consensus in the literature, this study sought to determine if a protocol of measuring serum estradiol and progesterone the day prior to frozen embryo transfer (FET) improves likelihood of pregnancy and livebirth. METHODS: This was a retrospective time-series study of women undergoing autologous vitrified-warmed blastocyst programmed FETs at an academic institution. Live birth rates were compared between a surveillance protocol, where serum estrogen and progesterone surveillance are performed the day prior to a programmed FET, and a standard protocol, whereby no hormonal lab evaluation is performed the day prior. RESULTS: Three hundred seventy-nine standard FET and 524 surveillance FET cycles were performed. Patients in the surveillance protocol were significantly more likely to achieve live birth (51% vs. 39%; aOR 1.6, 95%CI [1.2, 2.2]). Obese women were noted to be more likely to have lower progesterone hormone levels on surveillance labs (OR 3.2, 95%CI [2.0, 5.3]). However those whose hormonal medication dose was modified because of pre-transfer labs were as likely to achieve live birth as those whose dose was not modified (47% vs. 53%; aOR 0.8, 95%CI [0.6, 1.2]). CONCLUSIONS: Cycles with the surveillance protocol were more likely to result in live birth. Patients with low levels of pre-transfer hormones, such as obese patients, likely have lower pregnancy rates. It is possible that when these levels were corrected after measurement, pregnancy rates improved to match those whose levels were not low enough to warrant intervention. |
format | Online Article Text |
id | pubmed-7155246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-71552462020-04-20 Measuring serum estradiol and progesterone one day prior to frozen embryo transfer improves live birth rates Alur-Gupta, Snigdha Hopeman, Margaret Berger, Dara S. Barnhart, Kurt T. Senapati, Suneeta Gracia, Clarisa Fertil Res Pract Research Article BACKGROUND: Given no consensus in the literature, this study sought to determine if a protocol of measuring serum estradiol and progesterone the day prior to frozen embryo transfer (FET) improves likelihood of pregnancy and livebirth. METHODS: This was a retrospective time-series study of women undergoing autologous vitrified-warmed blastocyst programmed FETs at an academic institution. Live birth rates were compared between a surveillance protocol, where serum estrogen and progesterone surveillance are performed the day prior to a programmed FET, and a standard protocol, whereby no hormonal lab evaluation is performed the day prior. RESULTS: Three hundred seventy-nine standard FET and 524 surveillance FET cycles were performed. Patients in the surveillance protocol were significantly more likely to achieve live birth (51% vs. 39%; aOR 1.6, 95%CI [1.2, 2.2]). Obese women were noted to be more likely to have lower progesterone hormone levels on surveillance labs (OR 3.2, 95%CI [2.0, 5.3]). However those whose hormonal medication dose was modified because of pre-transfer labs were as likely to achieve live birth as those whose dose was not modified (47% vs. 53%; aOR 0.8, 95%CI [0.6, 1.2]). CONCLUSIONS: Cycles with the surveillance protocol were more likely to result in live birth. Patients with low levels of pre-transfer hormones, such as obese patients, likely have lower pregnancy rates. It is possible that when these levels were corrected after measurement, pregnancy rates improved to match those whose levels were not low enough to warrant intervention. BioMed Central 2020-04-14 /pmc/articles/PMC7155246/ /pubmed/32313664 http://dx.doi.org/10.1186/s40738-020-00075-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Alur-Gupta, Snigdha Hopeman, Margaret Berger, Dara S. Barnhart, Kurt T. Senapati, Suneeta Gracia, Clarisa Measuring serum estradiol and progesterone one day prior to frozen embryo transfer improves live birth rates |
title | Measuring serum estradiol and progesterone one day prior to frozen embryo transfer improves live birth rates |
title_full | Measuring serum estradiol and progesterone one day prior to frozen embryo transfer improves live birth rates |
title_fullStr | Measuring serum estradiol and progesterone one day prior to frozen embryo transfer improves live birth rates |
title_full_unstemmed | Measuring serum estradiol and progesterone one day prior to frozen embryo transfer improves live birth rates |
title_short | Measuring serum estradiol and progesterone one day prior to frozen embryo transfer improves live birth rates |
title_sort | measuring serum estradiol and progesterone one day prior to frozen embryo transfer improves live birth rates |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155246/ https://www.ncbi.nlm.nih.gov/pubmed/32313664 http://dx.doi.org/10.1186/s40738-020-00075-2 |
work_keys_str_mv | AT alurguptasnigdha measuringserumestradiolandprogesteroneonedaypriortofrozenembryotransferimproveslivebirthrates AT hopemanmargaret measuringserumestradiolandprogesteroneonedaypriortofrozenembryotransferimproveslivebirthrates AT bergerdaras measuringserumestradiolandprogesteroneonedaypriortofrozenembryotransferimproveslivebirthrates AT barnhartkurtt measuringserumestradiolandprogesteroneonedaypriortofrozenembryotransferimproveslivebirthrates AT senapatisuneeta measuringserumestradiolandprogesteroneonedaypriortofrozenembryotransferimproveslivebirthrates AT graciaclarisa measuringserumestradiolandprogesteroneonedaypriortofrozenembryotransferimproveslivebirthrates |