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Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is a common metabolic syndrome. Imbalances between liver lipid output and input are the direct causes of NAFLD, and hepatic steatosis is the pathological premise and basis for NAFLD progression. Mutual interaction between endoplasmic reticulum stress (ERS) an...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155254/ https://www.ncbi.nlm.nih.gov/pubmed/32284046 http://dx.doi.org/10.1186/s12944-020-01210-0 |
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author | Wang, Jin He, Wanping Tsai, Ping-Ju Chen, Pei-Hsuan Ye, Manxiang Guo, Jiao Su, Zhengquan |
author_facet | Wang, Jin He, Wanping Tsai, Ping-Ju Chen, Pei-Hsuan Ye, Manxiang Guo, Jiao Su, Zhengquan |
author_sort | Wang, Jin |
collection | PubMed |
description | Nonalcoholic fatty liver disease (NAFLD) is a common metabolic syndrome. Imbalances between liver lipid output and input are the direct causes of NAFLD, and hepatic steatosis is the pathological premise and basis for NAFLD progression. Mutual interaction between endoplasmic reticulum stress (ERS) and oxidative stress play important roles in NAFLD pathogenesis. Notably, mitochondria-associated membranes (MAMs) act as a structural bridges for functional clustering of molecules, particularly for Ca(2+), lipids, and reactive oxygen species (ROS) exchange. Previous studies have examined the crucial roles of ERS and ROS in NAFLD and have shown that MAM structural and functional integrity determines normal ER- mitochondria communication. Upon disruption of MAM integrity, miscommunication directly or indirectly causes imbalances in Ca2+ homeostasis and increases ERS and oxidative stress. Here, we emphasize the involvement of MAMs in glucose and lipid metabolism, chronic inflammation and insulin resistance in NAFLD and summarize MAM-targeting drugs and compounds, most of which achieve their therapeutic or ameliorative effects on NAFLD by improving MAM integrity. Therefore, targeting MAMs may be a viable strategy for NAFLD treatment. This review provides new ideas and key points for basic NAFLD research and drug development centred on mitochondria and the endoplasmic reticulum. |
format | Online Article Text |
id | pubmed-7155254 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-71552542020-04-20 Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease Wang, Jin He, Wanping Tsai, Ping-Ju Chen, Pei-Hsuan Ye, Manxiang Guo, Jiao Su, Zhengquan Lipids Health Dis Review Nonalcoholic fatty liver disease (NAFLD) is a common metabolic syndrome. Imbalances between liver lipid output and input are the direct causes of NAFLD, and hepatic steatosis is the pathological premise and basis for NAFLD progression. Mutual interaction between endoplasmic reticulum stress (ERS) and oxidative stress play important roles in NAFLD pathogenesis. Notably, mitochondria-associated membranes (MAMs) act as a structural bridges for functional clustering of molecules, particularly for Ca(2+), lipids, and reactive oxygen species (ROS) exchange. Previous studies have examined the crucial roles of ERS and ROS in NAFLD and have shown that MAM structural and functional integrity determines normal ER- mitochondria communication. Upon disruption of MAM integrity, miscommunication directly or indirectly causes imbalances in Ca2+ homeostasis and increases ERS and oxidative stress. Here, we emphasize the involvement of MAMs in glucose and lipid metabolism, chronic inflammation and insulin resistance in NAFLD and summarize MAM-targeting drugs and compounds, most of which achieve their therapeutic or ameliorative effects on NAFLD by improving MAM integrity. Therefore, targeting MAMs may be a viable strategy for NAFLD treatment. This review provides new ideas and key points for basic NAFLD research and drug development centred on mitochondria and the endoplasmic reticulum. BioMed Central 2020-04-13 /pmc/articles/PMC7155254/ /pubmed/32284046 http://dx.doi.org/10.1186/s12944-020-01210-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Wang, Jin He, Wanping Tsai, Ping-Ju Chen, Pei-Hsuan Ye, Manxiang Guo, Jiao Su, Zhengquan Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease |
title | Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease |
title_full | Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease |
title_fullStr | Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease |
title_full_unstemmed | Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease |
title_short | Mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease |
title_sort | mutual interaction between endoplasmic reticulum and mitochondria in nonalcoholic fatty liver disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155254/ https://www.ncbi.nlm.nih.gov/pubmed/32284046 http://dx.doi.org/10.1186/s12944-020-01210-0 |
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