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Lipidomic profile and candidate biomarkers in septic patients

Sepsis is a severe disease with a high mortality rate. Identification and treatment in the initial hours of the disease improve outcomes. Some biomarkers like procalcitonin and C-reactive protein are used for diagnosis and to access sepsis prognosis and they can help in clinical decision-making, but...

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Autores principales: Mecatti, Giovana Colozza, Messias, Márcia Cristina Fernandes, de Oliveira Carvalho, Patrícia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155265/
https://www.ncbi.nlm.nih.gov/pubmed/32284068
http://dx.doi.org/10.1186/s12944-020-01246-2
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author Mecatti, Giovana Colozza
Messias, Márcia Cristina Fernandes
de Oliveira Carvalho, Patrícia
author_facet Mecatti, Giovana Colozza
Messias, Márcia Cristina Fernandes
de Oliveira Carvalho, Patrícia
author_sort Mecatti, Giovana Colozza
collection PubMed
description Sepsis is a severe disease with a high mortality rate. Identification and treatment in the initial hours of the disease improve outcomes. Some biomarkers like procalcitonin and C-reactive protein are used for diagnosis and to access sepsis prognosis and they can help in clinical decision-making, but none has sufficient specificity or sensitivity to be routinely employed in clinical practice. This review seeks to evaluate lipid metabolism alterations in patients with sepsis and the possibility of using the respective metabolites as biomarkers of the disease. A search of the main electronic biomedical databases was conducted for the 20-year period ending in February 2020, focused on primary research articles on biomarkers in sepsis. The keywords included sepsis, septic shock, biomarker, metabolomic, lipidomic and lysophosphatidylcoline. . It concludes that altered lipid profiles, along with the progress of the disease should provide new insights, enabling a better understanding of the pathogenic mechanisms and making it possible to design new early diagnosis and therapeutic procedures for sepsis.
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spelling pubmed-71552652020-04-20 Lipidomic profile and candidate biomarkers in septic patients Mecatti, Giovana Colozza Messias, Márcia Cristina Fernandes de Oliveira Carvalho, Patrícia Lipids Health Dis Review Sepsis is a severe disease with a high mortality rate. Identification and treatment in the initial hours of the disease improve outcomes. Some biomarkers like procalcitonin and C-reactive protein are used for diagnosis and to access sepsis prognosis and they can help in clinical decision-making, but none has sufficient specificity or sensitivity to be routinely employed in clinical practice. This review seeks to evaluate lipid metabolism alterations in patients with sepsis and the possibility of using the respective metabolites as biomarkers of the disease. A search of the main electronic biomedical databases was conducted for the 20-year period ending in February 2020, focused on primary research articles on biomarkers in sepsis. The keywords included sepsis, septic shock, biomarker, metabolomic, lipidomic and lysophosphatidylcoline. . It concludes that altered lipid profiles, along with the progress of the disease should provide new insights, enabling a better understanding of the pathogenic mechanisms and making it possible to design new early diagnosis and therapeutic procedures for sepsis. BioMed Central 2020-04-13 /pmc/articles/PMC7155265/ /pubmed/32284068 http://dx.doi.org/10.1186/s12944-020-01246-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Mecatti, Giovana Colozza
Messias, Márcia Cristina Fernandes
de Oliveira Carvalho, Patrícia
Lipidomic profile and candidate biomarkers in septic patients
title Lipidomic profile and candidate biomarkers in septic patients
title_full Lipidomic profile and candidate biomarkers in septic patients
title_fullStr Lipidomic profile and candidate biomarkers in septic patients
title_full_unstemmed Lipidomic profile and candidate biomarkers in septic patients
title_short Lipidomic profile and candidate biomarkers in septic patients
title_sort lipidomic profile and candidate biomarkers in septic patients
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155265/
https://www.ncbi.nlm.nih.gov/pubmed/32284068
http://dx.doi.org/10.1186/s12944-020-01246-2
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