NEUROVIRULENCE AND PERSISTENCY OF MOUSE HEPATITIS VIRUSES IN RATS

The murine coronavirus JHM induces in weanling rats different types of central nervous diseases ranging from an acute panencephalitis to a late demyelinating encephalomyelitis. The occurrence and rate of these different disease types is associated with the virus variant used for inoculation. Except...

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Detalles Bibliográficos
Autores principales: Wege, H., Koga, M., Stephenson, J.R., Siddell, S., ter Meulen, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 1980
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155488/
http://dx.doi.org/10.1016/B978-0-12-255850-4.50067-6
Descripción
Sumario:The murine coronavirus JHM induces in weanling rats different types of central nervous diseases ranging from an acute panencephalitis to a late demyelinating encephalomyelitis. The occurrence and rate of these different disease types is associated with the virus variant used for inoculation. Except for MHV 2, neurovirulence was not observed in four other murine coronavirus strains. The relationship of these coronaviruses to JHM was investigated by cross neutralization and oligonucleotide maps of their genomic RNA.

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